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Two New Cyototoxic Cardenolides from the Whole Plants of Adonis multiflora Nishikawa & Koki Ito

1
Graduate School of Biotechnology and Department of Oriental Medicine Biotechnology, Kyung Hee University, Yongin 446-701, Korea
2
Graduate School of Biotechnology and Department of Genetic Engineering, Kyung Hee University, Yongin 446-701, Korea
3
Department of Herbal Crop Research, National Institute of Horicultural and Herbal Science, RDA, Eumseong 369-873, Korea
*
Author to whom correspondence should be addressed.
Academic Editor: Derek J. McPhee
Molecules 2015, 20(11), 20823-20831; https://doi.org/10.3390/molecules201119722
Received: 4 September 2015 / Revised: 11 November 2015 / Accepted: 13 November 2015 / Published: 23 November 2015
(This article belongs to the Section Natural Products Chemistry)
A phytochemical investigation of the whole plants of Adonis multiflora Nishikawa & Koki Ito. resulted in the isolation and identification of two new cardenolides—adonioside A (1) and adonioside B (6)—as well as four known cardenolides: tupichinolide (2) oleandrine (3), cryptostigmin II (4), and cymarin (5). Their structures were elucidated on the basis of NMR, MS, and IR spectroscopic analyses. Compounds 1, 2, 5, and 6 showed significant cytotoxicity against six human cancer cell lines (HCT-116, HepG2, HeLa, SK-OV-3, and SK-MEL-5, and SK-BR-3). View Full-Text
Keywords: Adonis multiflora; adonioside A; adonioside B; cardenolide; cytotoxic activity Adonis multiflora; adonioside A; adonioside B; cardenolide; cytotoxic activity
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Jung, J.-W.; Baek, N.-I.; Hwang-Bo, J.; Lee, S.-S.; Park, J.-H.; Seo, K.-H.; Kwon, J.-H.; Oh, E.-J.; Lee, D.-Y.; Chung, I.-S.; Bang, M.-H. Two New Cyototoxic Cardenolides from the Whole Plants of Adonis multiflora Nishikawa & Koki Ito. Molecules 2015, 20, 20823-20831.

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