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Open AccessArticle

Two New N-Oxide Alkaloids from Stemona cochinchinensis

1
State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macao 999078, China
2
State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China
3
Department of Organic Chemistry, Faculty of Chemistry, Hanoi National University of Education, Hanoi 100000, Vietnam
*
Authors to whom correspondence should be addressed.
Molecules 2014, 19(12), 20257-20265; https://doi.org/10.3390/molecules191220257
Received: 24 October 2014 / Revised: 27 November 2014 / Accepted: 1 December 2014 / Published: 3 December 2014
(This article belongs to the Section Natural Products Chemistry)
Two new N-oxide alkaloids with pyrrolo[1,2-α]azepine skeleton, namely isoneostemocochinine-N-oxide (1) and neostemocochinine-N-oxide (2), as well as three known alkaloids with pyrido[1,2-α]azepine skeletons, were isolated and identified from the roots of Stemona cochinchinensis (Stemonaceae). The structures of these compounds were elucidated by 1D- and 2D-NMR spectra and other spectroscopic studies. Additionally, the 1H- and 13C-NMR characteristic of N-oxide Stemona alkaloids was summarized. Stemokerrin showed potent anti-tussive activity on citric acid-induced guinea pig model. View Full-Text
Keywords: Stemona cochinchinensis; Stemonaceae; N-oxide alkaloids; 1H- and 13C-NMR; anti-tussive activity Stemona cochinchinensis; Stemonaceae; N-oxide alkaloids; 1H- and 13C-NMR; anti-tussive activity
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MDPI and ACS Style

Lin, L.; Bao, H.; Wang, A.; Tang, C.; Dien, P.-H.; Ye, Y. Two New N-Oxide Alkaloids from Stemona cochinchinensis. Molecules 2014, 19, 20257-20265.

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