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Molecules 2014, 19(12), 20257-20265;

Two New N-Oxide Alkaloids from Stemona cochinchinensis

State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macao 999078, China
State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China
Department of Organic Chemistry, Faculty of Chemistry, Hanoi National University of Education, Hanoi 100000, Vietnam
Authors to whom correspondence should be addressed.
Received: 24 October 2014 / Revised: 27 November 2014 / Accepted: 1 December 2014 / Published: 3 December 2014
(This article belongs to the Section Natural Products Chemistry)
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Two new N-oxide alkaloids with pyrrolo[1,2-α]azepine skeleton, namely isoneostemocochinine-N-oxide (1) and neostemocochinine-N-oxide (2), as well as three known alkaloids with pyrido[1,2-α]azepine skeletons, were isolated and identified from the roots of Stemona cochinchinensis (Stemonaceae). The structures of these compounds were elucidated by 1D- and 2D-NMR spectra and other spectroscopic studies. Additionally, the 1H- and 13C-NMR characteristic of N-oxide Stemona alkaloids was summarized. Stemokerrin showed potent anti-tussive activity on citric acid-induced guinea pig model. View Full-Text
Keywords: Stemona cochinchinensis; Stemonaceae; N-oxide alkaloids; 1H- and 13C-NMR; anti-tussive activity Stemona cochinchinensis; Stemonaceae; N-oxide alkaloids; 1H- and 13C-NMR; anti-tussive activity

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Lin, L.; Bao, H.; Wang, A.; Tang, C.; Dien, P.-H.; Ye, Y. Two New N-Oxide Alkaloids from Stemona cochinchinensis. Molecules 2014, 19, 20257-20265.

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