Next Article in Journal
Mild Conditions for Deuteration of Primary and Secondary Arylamines for the Synthesis of Deuterated Optoelectronic Organic Molecules
Next Article in Special Issue
Effects of Selected Dietary Secondary Metabolites on Reactive Oxygen Species Production Caused by Iron(II) Autoxidation
Previous Article in Journal
The Crystal Structure and Morphology of 2,4,6,8,10,12-Hexanitro-2,4,6,8,10,12-hexaazaisowurtzitane (CL-20) p-Xylene Solvate: A Joint Experimental and Simulation Study
Previous Article in Special Issue
Efficacy Evaluation of a Multifunctional Cosmetic Formulation: The Benefits of a Combination of Active Antioxidant Substances
Article

Effects of the Continuous Administration of an Agaricus blazei Extract to Rats on Oxidative Parameters of the Brain and Liver during Aging

1
Department of Biochemistry, State University of Maringá, 87020900 Maringá, Brazil
2
Department of Morphological Sciences, State University of Maringá, 87020900 Maringá, Brazil
*
Author to whom correspondence should be addressed.
Molecules 2014, 19(11), 18590-18603; https://doi.org/10.3390/molecules191118590
Received: 7 October 2014 / Revised: 6 November 2014 / Accepted: 7 November 2014 / Published: 13 November 2014
(This article belongs to the Special Issue Natural Antioxidants and Ageing)
An investigation of the effects of an aqueous extract of Agaricus blazei, a medicinal mushroom, on the oxidative state of the brain and liver of rats during aging (7 to 23 months) was conducted. The treatment consisted in the daily intragastric administration of 50 mg/kg of the extract. The A. blazei treatment tended to maintain the ROS contents of the brain and liver at lower levels, but a significant difference was found only at the age of 23 months and in the brain. The TBARS levels in the brain were maintained at lower levels by the A. blazei treatment during the whole aging process with a specially pronounced difference at the age of 12 months. The total antioxidant capacity in the brain was higher in treated rats only at the age of 12 months. Compared with previous studies in which old rats (21 months) were treated during a short period of 21 days with 200 mg/kg, the effects of the A. blazei extract in the present study tended to be less pronounced. The results also indicate that the long and constant treatment presented a tendency of becoming less effective at ages above 12 months. View Full-Text
Keywords: aging; oxidative stress; oxidative damage; brain; liver; A. blazei treatment aging; oxidative stress; oxidative damage; brain; liver; A. blazei treatment
Show Figures

Figure 1

MDPI and ACS Style

De Sá-Nakanishi, A.B.; Soares, A.A.; Natali, M.R.M.; Comar, J.F.; Peralta, R.M.; Bracht, A. Effects of the Continuous Administration of an Agaricus blazei Extract to Rats on Oxidative Parameters of the Brain and Liver during Aging. Molecules 2014, 19, 18590-18603. https://doi.org/10.3390/molecules191118590

AMA Style

De Sá-Nakanishi AB, Soares AA, Natali MRM, Comar JF, Peralta RM, Bracht A. Effects of the Continuous Administration of an Agaricus blazei Extract to Rats on Oxidative Parameters of the Brain and Liver during Aging. Molecules. 2014; 19(11):18590-18603. https://doi.org/10.3390/molecules191118590

Chicago/Turabian Style

De Sá-Nakanishi, Anacharis B., Andréia A. Soares, Maria R.M. Natali, Jurandir F. Comar, Rosane M. Peralta, and Adelar Bracht. 2014. "Effects of the Continuous Administration of an Agaricus blazei Extract to Rats on Oxidative Parameters of the Brain and Liver during Aging" Molecules 19, no. 11: 18590-18603. https://doi.org/10.3390/molecules191118590

Find Other Styles

Article Access Map by Country/Region

1
Only visits after 24 November 2015 are recorded.
Back to TopTop