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Molecules 2013, 18(7), 8518-8523;

Two New Chiratane-Type Triterpenoids from Swertia kouitchensis

Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China
The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou 310003, China
Shantou Institute for Drug Control, Shantou 515041, China
State Clinical Research Center of TCM, Hubei 430061, China
Author to whom correspondence should be addressed.
Received: 5 June 2013 / Revised: 2 July 2013 / Accepted: 10 July 2013 / Published: 18 July 2013
(This article belongs to the Section Natural Products Chemistry)
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Two rare new chiratane-type triterpenoids, kouitchenoids A and B (1, 2), together with oleanolic acid (3) and ursolic acid (4), were isolated from ethanol extract of Swertia kouitchensis. The new structures were determined by the analysis of MS and NMR data. In addition, compounds 14 showed moderate inhibitory activity against the α-glucosidase (with IC50 values ranging from 1,812 to 2,027 μM). View Full-Text
Keywords: Swertia kouitchensis; diabetes; chiratane; triterpenoid; α-glucosidase Swertia kouitchensis; diabetes; chiratane; triterpenoid; α-glucosidase

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This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Wan, L.-S.; Liu, T.-T.; Lin, X.-J.; Min, Q.-X.; Chen, J.-C. Two New Chiratane-Type Triterpenoids from Swertia kouitchensis. Molecules 2013, 18, 8518-8523.

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