Palladium(II)-Catalyzed othro-C–H-Benzoxylation of 2-Arylpyridines by Oxidative Coupling with Aryl Acylperoxides
State Key Laboratory of Chirosciences and Department of Applied Biology and Chemical Technology, the Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong
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Molecules 2013, 18(4), 4403-4418; https://doi.org/10.3390/molecules18044403
Received: 5 March 2013 / Revised: 21 March 2013 / Accepted: 21 March 2013 / Published: 15 April 2013
A palladium(II)-catalyzed ortho-benzoxylation of 2-arylpyridines with aryl acylperoxides was developed. With pyridyl as directing group, the benzoxylation reaction exhibits remarkable regioselectivity and excellent functional group tolerance, providing the products in up to 87% yield.
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Sit, W.-N.; Chan, C.-W.; Yu, W.-Y. Palladium(II)-Catalyzed othro-C–H-Benzoxylation of 2-Arylpyridines by Oxidative Coupling with Aryl Acylperoxides. Molecules 2013, 18, 4403-4418.
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