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Molecules 2013, 18(12), 15126-15133; https://doi.org/10.3390/molecules181215126

Polyketides from the Halotolerant Fungus Myrothecium sp. GS-17

1
Department of Natural Products Chemistry, School of Pharmacy, China Medical University, Shenyang 110001, China
2
State Key Laboratory of Magnetic Resonance and Atomic and Molecular Physics, Wuhan Institute of Physics and Mathematics, Chinese Academy of Sciences, Wuhan 430071, China
3
Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, China
4
Institute of Applied Ecology, Chinese Academy of Sciences, Shenyang 110016, China
5
School of Life Science and Biopharmaceutics, Shenyang Pharmaceutical University, Shenyang 110016, China
*
Author to whom correspondence should be addressed.
Received: 12 November 2013 / Revised: 29 November 2013 / Accepted: 4 December 2013 / Published: 6 December 2013
(This article belongs to the Section Natural Products Chemistry)
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Abstract

Two new polyketides, myrothecol (1) and 5-hydroxy-3-methyl-4-(1- hydroxylethyl)-furan-2(5H)-one (2), were isolated from the fermentation broth of the halotolerant fungus Myrothecium sp. GS-17 along with three known compounds, 5-hydroxyl-3-[(1S)-1-hydroxyethyl]-4-methylfuran-2(5H)-one (3), 3,5-dimethyl-4- hydroxylmethyl-5-methoxyfuran-2(5H)-one (4), and 3,5-dimethyl-4-hydroxymethyl-5- hydroxyfuran-2(5H)-one (5). Compound 1 is the first natural occurring polyketide with a unique furylisobenzofuran skeleton. The structures of these compounds were established via extensive spectroscopic analyses including 1D-, 2D-NMR, HRESI-MS, and crystal X-ray diffraction analysis. View Full-Text
Keywords: halotolerant fungus; Myrothecium sp.; polyketide; furanone halotolerant fungus; Myrothecium sp.; polyketide; furanone
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Liu, T.; Zhu, J.; Zhang, S.-Y.; Li, Z.-L.; Guan, L.-P.; Pan, H.-Q.; Wu, X.; Bai, J.; Hua, H.-M. Polyketides from the Halotolerant Fungus Myrothecium sp. GS-17. Molecules 2013, 18, 15126-15133.

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