The Novel [4,5-e][1,3]Diazepine-4,8-dione and Acyclic Carbamoyl Imino-Ureido Derivatives of Imidazole: Synthesis, Anti-Viral and Anti-Tumor Activity Evaluations
Abstract
:1. Introduction
2. Results and Discussion
2.1. Chemistry
2.2. Structural Properties
2.3. Biological Results
2.3.2. Cytostatic Activity
Tumor cell growth IC50a (μM) | ||||||
---|---|---|---|---|---|---|
Compd. | Structure | Cell lines | ||||
MCF-7 | HepG2 | SW620 | HeLa | BJ | ||
1 | >100 | >100 | >100 | 24 | >100 | |
2 | >100 | >100 | >100 | >100 | >100 | |
3 | >100 | >100 | >100 | 9.5 | >100 | |
4 | >100 | >100 | >100 | >100 | >100 | |
5 | >100 | >100 | >100 | 32 | >100 | |
6 | >100 | >100 | >100 | >100 | >100 | |
7 | >100 | >100 | >100 | >100 | >100 | |
8 | >100 | >100 | >100 | >100 | >100 | |
9 | >100 | >100 | >100 | >100 | >100 | |
10 | >100 | 41 | 31 | 31 | >100 | |
11 | >100 | >100 | 20 | >100 | >100 | |
12 | >100 | >100 | >100 | >100 | >100 |
3. Experimental
3.1. General Materials and Methods
3.2. Procedures for the Preparations of Compounds
3.2.1. General Procedure for Synthesis of 1–4
3.2.2. General Procedure for Synthesis of 5–8
3.2.3. General Procedure for Synthesis of 9–11
3.2.4. General Procedure for Synthesis of 12–13
3.3. Biological Methods
3.3.1. Cell Culturing
3.3.2. Proliferation Assays
4. Conclusions
Acknowledgments
Conflicts of Interest
References
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Wittine, K.; Poljak, K.; Kovač, M.; Makuc, D.; Plavec, J.; Balzarini, J.; Martinović, T.; Pavelić, S.K.; Pavelić, K.; Mintas, M. The Novel [4,5-e][1,3]Diazepine-4,8-dione and Acyclic Carbamoyl Imino-Ureido Derivatives of Imidazole: Synthesis, Anti-Viral and Anti-Tumor Activity Evaluations. Molecules 2013, 18, 13385-13397. https://doi.org/10.3390/molecules181113385
Wittine K, Poljak K, Kovač M, Makuc D, Plavec J, Balzarini J, Martinović T, Pavelić SK, Pavelić K, Mintas M. The Novel [4,5-e][1,3]Diazepine-4,8-dione and Acyclic Carbamoyl Imino-Ureido Derivatives of Imidazole: Synthesis, Anti-Viral and Anti-Tumor Activity Evaluations. Molecules. 2013; 18(11):13385-13397. https://doi.org/10.3390/molecules181113385
Chicago/Turabian StyleWittine, Karlo, Kristina Poljak, Matea Kovač, Damjan Makuc, Janez Plavec, Jan Balzarini, Tamara Martinović, Sandra Kraljević Pavelić, Krešimir Pavelić, and Mladen Mintas. 2013. "The Novel [4,5-e][1,3]Diazepine-4,8-dione and Acyclic Carbamoyl Imino-Ureido Derivatives of Imidazole: Synthesis, Anti-Viral and Anti-Tumor Activity Evaluations" Molecules 18, no. 11: 13385-13397. https://doi.org/10.3390/molecules181113385