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Ameliorative Effects of Curculigoside from Curculigo orchioides Gaertn on Learning and Memory in Aged Rats

Department of Geraeology, First Affiliated Hospital of Suzhou University, Suzhou 215006, China
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Molecules 2012, 17(9), 10108-10118; https://doi.org/10.3390/molecules170910108
Received: 13 June 2012 / Revised: 29 July 2012 / Accepted: 9 August 2012 / Published: 24 August 2012
(This article belongs to the Section Natural Products Chemistry)
This study was designed to evaluate the ameliorating effects of curculigoside from Curculigo orchioides Gaertn on learning and memory in aged rats. In the present study, the ameliorating effects of curculigoside were determined through animal behaviour studies (including step-down test and Y-maze test), and the possible mechanisms were explored by evaluation of the activity of acetylcholinesterase (AchE) and determination of the expression of BACE1. Oral adminstration of the curculigoside (20, 40 mg/kg/day) for 14 days can significantly improve the latency and number of errors in aged rats based on the behaviour study results. In addition, the activity of AchE can be decreased by treatment of the curculigoside (10, 20, 40 mg/kg/day). Moreover, the expression of BACE1 can be down-regulated in the hippocampus of aged rats treated with curculigoside. The results of our present work have indicated that curculigoside can improve cognitive function in aged animals, possibly by decreasing the activity of AchE in the cerebra and inhibiting the expression of BACE1 in the hippocampus. In conclusion, our results suggested that curculigoside can be possible developed as a new drug for the treatment of Alzheimer’s disease in the future. View Full-Text
Keywords: curculigoside; Curculigo orchioides; Alzheimer’s disease; behaviour study; ameliorative effects on learning and memory curculigoside; Curculigo orchioides; Alzheimer’s disease; behaviour study; ameliorative effects on learning and memory
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Wu, X.-Y.; Li, J.-Z.; Guo, J.-Z.; Hou, B.-Y. Ameliorative Effects of Curculigoside from Curculigo orchioides Gaertn on Learning and Memory in Aged Rats. Molecules 2012, 17, 10108-10118.

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