Antibacterial, Antifungal and Cytotoxic Activities of Two Flavonoids from Retama raetam Flowers
1
Laboratoire des Maladies Transmissibles et des Substances Biologiquement Actives, Faculté de Pharmacie, Monastir 5000, Tunisia
2
Laboratoire de Microbiologie C H U Fattouma BOURGUIBA, Monastir 5000, Tunisia
3
Laboratoire de Chimie des Substances Naturelles et de Synthèse Organique 99/UR/12-26, Faculté des Sciences de Monastir, Monastir 5000, Tunisia
4
Division of Toxicology, Scientific Institute of Public Health, Brussels B-1050, Belgium
5
Department of Biomedical Sciences, University of Antwerp, Wilrijk 2610, Belgium
*
Author to whom correspondence should be addressed.
Molecules 2012, 17(6), 7284-7293; https://doi.org/10.3390/molecules17067284
Received: 16 May 2012 / Revised: 29 May 2012 / Accepted: 6 June 2012 / Published: 13 June 2012
(This article belongs to the Section Natural Products Chemistry)
We have investigated the antibacterial, antifungal and cytotoxic activities of two flavonoids isolated from Retama raetam flowers using the disc diffusion and micro-dilution broth methods. The cytotoxic activity was tested against Hep-2 cells using the MTT assay. The compounds licoflavone C (1) and derrone (2) were active against Pseudomonas aeruginosa and Escherichia coli (7.81–15.62 µg/mL) and showed important antifungal activity. Strong antifungal activity against Candida species (7.81 µg/mL) was for example found with compound 2. The tested compounds also showed strong cytotoxicity against Hep-2 cells. These two compounds may be interesting antimicrobial agents to be used against infectious diseases caused by many pathogens.
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Keywords:
Retama raetam flowers; antibacterial activity; antifungal activity; cytotoxic property; flavonoid
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MDPI and ACS Style
Edziri, H.; Mastouri, M.; Mahjoub, M.A.; Mighri, Z.; Mahjoub, A.; Verschaeve, L. Antibacterial, Antifungal and Cytotoxic Activities of Two Flavonoids from Retama raetam Flowers. Molecules 2012, 17, 7284-7293.
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