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Antiproliferative and Molecular Mechanism of Eugenol-Induced Apoptosis in Cancer Cells

Department of Biomedical Engineering, PSNA college of Engineering and Technology, Kothandaraman Nagar, Dindigul 624622, Tamil Nadu, India
Department of Clinical science and Engineering, University Technology Malaysia, Johor bahru 81310, Malaysia
Author to whom correspondence should be addressed.
Molecules 2012, 17(6), 6290-6304;
Received: 28 March 2012 / Revised: 28 April 2012 / Accepted: 9 May 2012 / Published: 25 May 2012
(This article belongs to the Section Natural Products Chemistry)
Phenolic phytochemicals are a broad class of nutraceuticals found in plants which have been extensively researched by scientists for their health-promoting potential. One such a compound which has been comprehensively used is eugenol (4-allyl-2-methoxyphenol), which is the active component of Syzigium aromaticum (cloves). Aromatic plants like nutmeg, basil, cinnamon and bay leaves also contain eugenol. Eugenol has a wide range of applications like perfumeries, flavorings, essential oils and in medicine as a local antiseptic and anesthetic. Increasing volumes of literature showed eugenol possesses antioxidant, antimutagenic, antigenotoxic, anti-inflammatory and anticancer properties. Molecular mechanism of eugenol-induced apoptosis in melanoma, skin tumors, osteosarcoma, leukemia, gastric and mast cells has been well documented. This review article will highlight the antiproliferative activity and molecular mechanism of the eugenol induced apoptosis against the cancer cells and animal models. View Full-Text
Keywords: eugenol; antiproliferative; cancer; chemoprevention eugenol; antiproliferative; cancer; chemoprevention
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Jaganathan, S.K.; Supriyanto, E. Antiproliferative and Molecular Mechanism of Eugenol-Induced Apoptosis in Cancer Cells. Molecules 2012, 17, 6290-6304.

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