Norcembranoidal Diterpenes from a Formosan Soft Coral Sinularia sp.
Abstract
:1. Introduction
2. Results and Discussion
3. Experimental
3.1. General Procedures
3.2. Animal Material
3.3. Extraction and Isolation
3.4. Molecular Mechanics Calculations
3.5. Cytotoxicity Testing
4. Conclusions
Acknowledgments
References
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Sample Availability: Not available. |
Position | δΗ (J in Hz) | δC, Mult. | 1H–1H COSY | HMBC (H→C) |
---|---|---|---|---|
1 | 2.99 m | 39.6, CH | H2-2, H2-14 | C-15 |
2α β | 2.65 m 2.52 m | 45.9, CH2 | H-1, H-2β H-1, H-2α | C-1, -3, -14, -15 C-1, -3, -14, -15 |
3 | 205.3, C | |||
4α β | 2.53 dd (16.4, 8.8) 2.82 dd (16.4, 2.4) | 43.1, CH2 | H-4β, H-5 H-4α, H-5 | C-3, -5, -6 C-3, -5, -6 |
5 | 4.27 dd (8.8, 2.4) | 75.0, CH | H2-4 | C-3, -4 |
6 | 214.5, C | |||
7α β | 2.60 m 2.46 m | 51.1, CH2 | H-7β H-7α | C-5, -6, -8, -9, -18 C-5, -6, -8, -9, -18 |
8 | 79.0, C | |||
9α β | 2.34 m 2.47 m | 41.8, CH2 | H-9β, H-10 H-9α, H-10 | C-7, -8, -10, -11, -18 C-7, -8, -10, -11, -18 |
10 | 4.52 dt (6.8, 2.0) | 80.8, CH | H2-9, H-11 | C-8, -11, -19 |
11 | 5.47 br s | 76.4, CH | H-10 | C-9, -12, -13, -19, acetate carbonyl |
12 | 127.6, C | |||
13 | 6.45 ddd (10.8, 4.4, 1.2) | 147.2, CH | H2-14 | C-1, -11, -19 |
14α β | 2.20 ddd (14.8, 4.4, 3.6) 3.78 ddd (14.8, 10.8, 6.8) | 28.4, CH2 | H-1, H-13 H-1, H-13 | C-1, -2, -12, -13, -15 C-1, -2, -12, -13, -15 |
15 | 147.0, C | |||
16a b | 4.86 s 4.79 s | 110.4, CH2 | H-16b, H3-17 H-16a, H3-17 | C-1, -15, -17 C-1, -15, -17 |
17 | 1.80 s | 21.6, CH3 | H2-16 | C-1, -15, -16 |
18 | 1.42 s | 26.5, CH3 | C-7, -8, -9 | |
19 | 167.7, C | |||
11-OAc | 2.08 s | 171.2, C20.9, CH3 | Acetate carbonyl |
Compounds | Cell lines IC50 (μg/mL) | |||||
---|---|---|---|---|---|---|
K562 | MOLT-4 | HTC-116 | DLD-1 | T-47D | MDA-MB-231 | |
1 | 0.67 | 0.59 | 4.09 | 0.92 | 3.09 | 2.95 |
2 | NA | NA | NA | NA | NA | NA |
Doxorubicin a | 0.15 | 0.01 | 1.11 | 0.22 | 0.40 | 1.30 |
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Share and Cite
Yen, W.-H.; Hu, L.-C.; Su, J.-H.; Lu, M.-C.; Twan, W.-H.; Yang, S.-Y.; Kuo, Y.-C.; Weng, C.-F.; Lee, C.-H.; Kuo, Y.-H.; et al. Norcembranoidal Diterpenes from a Formosan Soft Coral Sinularia sp. Molecules 2012, 17, 14058-14066. https://doi.org/10.3390/molecules171214058
Yen W-H, Hu L-C, Su J-H, Lu M-C, Twan W-H, Yang S-Y, Kuo Y-C, Weng C-F, Lee C-H, Kuo Y-H, et al. Norcembranoidal Diterpenes from a Formosan Soft Coral Sinularia sp. Molecules. 2012; 17(12):14058-14066. https://doi.org/10.3390/molecules171214058
Chicago/Turabian StyleYen, Wei-Hsuan, Li-Chung Hu, Jui-Hsin Su, Mei-Chin Lu, Wen-Hung Twan, Show-Ying Yang, Yung-Chi Kuo, Ching-Feng Weng, Chia-Hung Lee, Yueh-Hsiung Kuo, and et al. 2012. "Norcembranoidal Diterpenes from a Formosan Soft Coral Sinularia sp." Molecules 17, no. 12: 14058-14066. https://doi.org/10.3390/molecules171214058