Fabrication of Mesoporous Silica Shells on Solid Silica Spheres Using Anionic Surfactants and Their Potential Application in Controlling Drug Release
Abstract
:1. Introduction
2. Results and Discussion
2.1. Effect of Synthesis Route
Sample code | Synthesis route | Synthesis temperature/°C | Synthesis time | Surface area/cm2·g−1 | Pore volume/cc·g−1 | Shell thickness/nm | Pore size/nm | |
---|---|---|---|---|---|---|---|---|
TTEM | TDLS | |||||||
SCMS-1 | One pot | 25 | 20 h | 7 | 0.008 | 34 | 38 | 3.6, 4, 6 |
SCMS-2 | Two pot | 25 | 20 h | 199 | 0.207 | 41 | 43 | 3.6, 10 |
SCMS-3 | Two pot | 50 | 20 h | 191 | 0.234 | 58 | 57 | 3.6, 10 |
SCMS-4 | Two pot | 80 | 20 h | 286 | 0.243 | 65 | 71 | 3.6 |
SCMS-5 | Two pot | 80 | 6 h | 324 | 0.261 | 50 | 53 | 3.6 |
SCMS-6 | Two pot | 80 | 2 h | 226 | 0.184 | 42 | 46 | 3.6 |
Hexa-an | - | 25 | 20 h | 332 | 0.354 | - | - | 3.6 |
2.2. Effect of Reaction Temperature
2.3. Effect of Reaction Time
3. Experimental
3.1. Chemicals
3.2. Synthesis
3.2.1. Synthesis of Solid Silica Cores
3.2.2. One-Pot Synthesis Route
3.2.3. Two-Pot Synthesis Route
3.2.4. In-Vitro Drug Storage Study
3.2.5. In Vitro Drug Release Study
3.3. Characterization
4. Conclusions
Acknowledgments
- Sample Availability: Small quantities, in micrograms, of the core-mesoporous shell silica spheres samples are available from the authors on request.
References
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El-Toni, A.M.; Khan, A.; Ibrahim, M.A.; Al-Hoshan, M.; Labis, J.P. Fabrication of Mesoporous Silica Shells on Solid Silica Spheres Using Anionic Surfactants and Their Potential Application in Controlling Drug Release. Molecules 2012, 17, 13199-13210. https://doi.org/10.3390/molecules171113199
El-Toni AM, Khan A, Ibrahim MA, Al-Hoshan M, Labis JP. Fabrication of Mesoporous Silica Shells on Solid Silica Spheres Using Anionic Surfactants and Their Potential Application in Controlling Drug Release. Molecules. 2012; 17(11):13199-13210. https://doi.org/10.3390/molecules171113199
Chicago/Turabian StyleEl-Toni, Ahmed Mohamed, Aslam Khan, Mohamed Abbas Ibrahim, Mansour Al-Hoshan, and Joselito Puzon Labis. 2012. "Fabrication of Mesoporous Silica Shells on Solid Silica Spheres Using Anionic Surfactants and Their Potential Application in Controlling Drug Release" Molecules 17, no. 11: 13199-13210. https://doi.org/10.3390/molecules171113199
APA StyleEl-Toni, A. M., Khan, A., Ibrahim, M. A., Al-Hoshan, M., & Labis, J. P. (2012). Fabrication of Mesoporous Silica Shells on Solid Silica Spheres Using Anionic Surfactants and Their Potential Application in Controlling Drug Release. Molecules, 17(11), 13199-13210. https://doi.org/10.3390/molecules171113199