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Communication

The Newly Isolated Endophytic Fungus Paraconiothyrium sp. LK1 Produces Ascotoxin

by
Abdul Latif Khan
1,2,
Muhammad Hamayun
3,
Javid Hussain
2,4,
Sang-Mo Kang
1 and
In-Jung Lee
1,*
1
School of Applied Biosciences, College of Agriculture and Life Sciences, Kyungpook National University, Daegu 702-701, Korea
2
Department of Plant Sciences, Kohat University of Science and Technology, Kohat 26000, Pakistan
3
Department of Botany, Abdul Wali Khan University, Mardan 23300, Pakistan
4
Department of Biological Sciences and Chemistry, College of Arts & Sciences, University of Nizwa, Nizwa 33, Oman
*
Author to whom correspondence should be addressed.
Molecules 2012, 17(1), 1103-1112; https://doi.org/10.3390/molecules17011103
Submission received: 19 December 2011 / Revised: 6 January 2012 / Accepted: 11 January 2012 / Published: 20 January 2012
(This article belongs to the Section Natural Products Chemistry)
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Abstract

We have isolated five endophytic fungi from the roots of Capsicum annuum, Cucumis sativus and Glycine max. The culture filtrates (CF) of these endophytes were screened on dwarf mutant rice (Waito-C) and normal rice (Dongjin-byeo). Endophyte CAC-1A significantly inhibited the growth of Waito-C and Dongjin-byeo. Endophyte CAC-1A was identified as Paraconiothyrium sp. by sequencing the ITS rDNA region and phylogenetic analysis. The ethyl acetate fraction of Paraconiothyrium sp. suppressed the germination of Lactuca sativa and Echinochloa crus-galli seeds. The ethyl acetate fraction of the endophyte was subjected to bioassay-guided isolation and we obtained the phytotoxic compound ascotoxin (1) which was characterized through NMR and GC/MS techniques. Ascotoxin revealed 100% inhibitory effects on seed germination of Echinochloa crus-galli. Compound (1) was isolated for the first time from Paraconiothyrium sp.
Keywords: Paraconiothyrium sp.; ascotoxin; growth inhibitory effect; endophytic fungi Paraconiothyrium sp.; ascotoxin; growth inhibitory effect; endophytic fungi

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MDPI and ACS Style

Khan, A.L.; Hamayun, M.; Hussain, J.; Kang, S.-M.; Lee, I.-J. The Newly Isolated Endophytic Fungus Paraconiothyrium sp. LK1 Produces Ascotoxin. Molecules 2012, 17, 1103-1112. https://doi.org/10.3390/molecules17011103

AMA Style

Khan AL, Hamayun M, Hussain J, Kang S-M, Lee I-J. The Newly Isolated Endophytic Fungus Paraconiothyrium sp. LK1 Produces Ascotoxin. Molecules. 2012; 17(1):1103-1112. https://doi.org/10.3390/molecules17011103

Chicago/Turabian Style

Khan, Abdul Latif, Muhammad Hamayun, Javid Hussain, Sang-Mo Kang, and In-Jung Lee. 2012. "The Newly Isolated Endophytic Fungus Paraconiothyrium sp. LK1 Produces Ascotoxin" Molecules 17, no. 1: 1103-1112. https://doi.org/10.3390/molecules17011103

APA Style

Khan, A. L., Hamayun, M., Hussain, J., Kang, S.-M., & Lee, I.-J. (2012). The Newly Isolated Endophytic Fungus Paraconiothyrium sp. LK1 Produces Ascotoxin. Molecules, 17(1), 1103-1112. https://doi.org/10.3390/molecules17011103

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