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Anti-Inflammatory Activity of Methyl Salicylate Glycosides Isolated from Gaultheria yunnanensis (Franch.) Rehder

1,3, 1,3, 1,3, 1,3, 2,3, 2,3, 1,3,* and 1,3,*
1
National Center for Pharmaceutical Screening, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, China
2
Department of Phytochemistry, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, China
3
Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Ministry of Education, Beijing 100050, China
*
Authors to whom correspondence should be addressed.
Molecules 2011, 16(5), 3875-3884; https://doi.org/10.3390/molecules16053875
Received: 12 February 2010 / Revised: 28 April 2011 / Accepted: 6 May 2011 / Published: 9 May 2011
(This article belongs to the Section Natural Products Chemistry)
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Abstract

Gaultheria yunnanensis (Franch.) Rehder is a kind of traditional Chinese herbal medicine used for the treatments of rheumatoid arthritis, swelling and pain. Two methyl salicylate glycosides, namely methyl benzoate-2-O-b-D-xylopyranosyl(1-6)-O-b-D-gluco-pyranoside (J12122) and methyl benzoate-2-O-β-D-xylopyranosyl(1-2)[O-β-D-xylopyranosyl(1-6)]-O-β-D-glucopyranoside (J12123), are natural salicylic derivatives isolated from Gaultheria yunnanensis. In this study, we investigated the anti-inflammatory activity of J12122 and J12123 on LPS-induced RAW264.7 macrophage cells by measuring the production of pro-inflammatory cytokines, accumulation of nitric oxide (NO), and level of reactive oxygen species (ROS). The results showed that both methyl salicylate glycosides dose-dependently inhibited the production of tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β), and IL-6, respectively. Consistent with these observations, J12122 and J12123 significantly suppressed the accumulation of NO, with an inhibitory rate of 56.20% and 51.72% at 3.0 μg/mL concentration, respectively. Furthermore, the two methyl salicylate glycosides reduced the level of ROS induced by LPS. These results showed that the isolated compounds possess anti-inflammatory properties through inhibition the production pro-inflammatory cytokines, NO, and ROS. View Full-Text
Keywords: Gaultheria plant; anti-inflammation; methyl salicylicate glycoside; inflammatory cytokines Gaultheria plant; anti-inflammation; methyl salicylicate glycoside; inflammatory cytokines
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Zhang, D.; Liu, R.; Sun, L.; Huang, C.; Wang, C.; Zhang, D.-M.; Zhang, T.-T.; Du, G.-H. Anti-Inflammatory Activity of Methyl Salicylate Glycosides Isolated from Gaultheria yunnanensis (Franch.) Rehder. Molecules 2011, 16, 3875-3884.

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