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Molecules 2011, 16(3), 2443-2466;

Allobetulin and Its Derivatives: Synthesis and Biological Activity

Molecular Design and Synthesis, Department of Chemistry, University of Leuven, Celestijnenlaan 200F, 3-3001 Leuven, Belgium
Department of Chemistry, The L.N.Gumilev Eurasian National University, Munaitpasov str. 5, 010008 Astana, Kazakhstan
Department of Biochemistry, Medical University “Astana”, Beybetshilyk. 51, 010000 Astana, Kazakhstan
Author to whom correspondence should be addressed.
Received: 22 February 2011 / Revised: 9 March 2011 / Accepted: 11 March 2011 / Published: 14 March 2011


This review covers the chemistry of allobetulin analogs, including their formation by rearrangement from betulin derivatives, their further derivatisation, their fusion with heterocyclic rings, and any further rearrangements of allobetulin compounds including ring opening, ring contraction and ring expansion reactions. In the last part, the most important biological activities of allobetulin derivatives are listed. One hundred and fifteen references are cited and the relevant literature is covered, starting in 1922 up to the end of 2010. View Full-Text
Keywords: triterpene; allobetulin; rearrangement; biological activity triterpene; allobetulin; rearrangement; biological activity

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This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Dehaen, W.; Mashentseva, A.A.; Seitembetov, T.S. Allobetulin and Its Derivatives: Synthesis and Biological Activity. Molecules 2011, 16, 2443-2466.

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