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Open AccessArticle

From Symmetric Glycerol Derivatives to Dissymmetric Chlorohydrins

Department of Chemistry, Lleida University, Alcalde Rovira Roure 191, 25198 Lleida, Spain
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Molecules 2011, 16(3), 2065-2074; https://doi.org/10.3390/molecules16032065
Received: 9 December 2010 / Revised: 16 February 2011 / Accepted: 28 February 2011 / Published: 2 March 2011
(This article belongs to the Special Issue Asymmetric Synthesis)
The anticipated worldwide increase in biodiesel production will result in an accumulation of glycerol for which there are insufficient conventional uses. The surplus of this by-product has increased rapidly during the last decade, prompting a search for new glycerol applications. We describe here the synthesis of dissymmetric chlorohydrin esters from symmetric 1,3-dichloro-2-propyl esters obtained from glycerol. We studied the influence of two solvents: 1,4-dioxane and 1-butanol and two bases: sodium carbonate and 1-butylimidazole, on the synthesis of dissymmetric chlorohydrin esters. In addition, we studied the influence of other bases (potassium and lithium carbonates) in the reaction using 1,4-dioxane as the solvent. The highest yield was obtained using 1,4-dioxane and sodium carbonate. View Full-Text
Keywords: glycerol; chlorohydrin esters; dissymmetry; 1-butanol; 1,4-dioxane glycerol; chlorohydrin esters; dissymmetry; 1-butanol; 1,4-dioxane
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MDPI and ACS Style

Solarte, C.; Escribà, M.; Eras, J.; Villorbina, G.; Canela, R.; Balcells, M. From Symmetric Glycerol Derivatives to Dissymmetric Chlorohydrins. Molecules 2011, 16, 2065-2074.

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