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Synthesis and Biological Evaluation of a γ-Cyclodextrin-based Formulation of the Anticancer Agent 5,6,11,12,17,18,23,24- Octahydrocyclododeca[1,2-b:4,5-b’:7,8-b’’:10,11-b’’’]tetraindole (CTet)

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Dipartimento di Scienze del Farmaco e della Salute, Università degli Studi di Urbino “Carlo Bo” I- 61029 Urbino, Piazza del Rinascimento 6, Italy
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Dipartimento di Scienze Biomolecolari, Università degli Studi di Urbino “Carlo Bo” I-61029 Urbino, Via Aurelio Saffi 2, Italy
*
Author to whom correspondence should be addressed.
Molecules 2010, 15(6), 4085-4093; https://doi.org/10.3390/molecules15064085
Received: 21 April 2010 / Revised: 27 May 2010 / Accepted: 1 June 2010 / Published: 4 June 2010
5,6,11,12,17,18,23,24-octahydrocyclododeca[1,2-b:4,5-b’:7,8-b’’:10,11- b’’’]tetrai ndole (CTet), an indole-3-carbinol (I3C) metabolite endowed with anticancer properties, is poorly soluble in the solvents most frequently used in biological tests. This study indicates that the use of γ-cyclodextrin (γ-CD) avoids this problem. Formulated with γ-CD CTet is a potent inhibitor of DNA synthesis in both estrogen receptor positive (MCF-7) and estrogen receptor negative (MDA-MB-231) human breast cell lines (IC50 = 1.20 ± 0.04 μM and 1.0 ± 0.1 μM, respectively). View Full-Text
Keywords: indole-3-carbinol; indole cyclic tetramer; γ-cyclodextrin; breast cancer indole-3-carbinol; indole cyclic tetramer; γ-cyclodextrin; breast cancer
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MDPI and ACS Style

Lucarini, S.; De Santi, M.; Antonietti, F.; Brandi, G.; Diamantini, G.; Fraternale, A.; Paoletti, M.F.; Tontini, A.; Magnani, M.; Duranti, A. Synthesis and Biological Evaluation of a γ-Cyclodextrin-based Formulation of the Anticancer Agent 5,6,11,12,17,18,23,24- Octahydrocyclododeca[1,2-b:4,5-b’:7,8-b’’:10,11-b’’’]tetraindole (CTet). Molecules 2010, 15, 4085-4093. https://doi.org/10.3390/molecules15064085

AMA Style

Lucarini S, De Santi M, Antonietti F, Brandi G, Diamantini G, Fraternale A, Paoletti MF, Tontini A, Magnani M, Duranti A. Synthesis and Biological Evaluation of a γ-Cyclodextrin-based Formulation of the Anticancer Agent 5,6,11,12,17,18,23,24- Octahydrocyclododeca[1,2-b:4,5-b’:7,8-b’’:10,11-b’’’]tetraindole (CTet). Molecules. 2010; 15(6):4085-4093. https://doi.org/10.3390/molecules15064085

Chicago/Turabian Style

Lucarini, Simone, Mauro De Santi, Francesca Antonietti, Giorgio Brandi, Giuseppe Diamantini, Alessandra Fraternale, Maria Filomena Paoletti, Andrea Tontini, Mauro Magnani, and Andrea Duranti. 2010. "Synthesis and Biological Evaluation of a γ-Cyclodextrin-based Formulation of the Anticancer Agent 5,6,11,12,17,18,23,24- Octahydrocyclododeca[1,2-b:4,5-b’:7,8-b’’:10,11-b’’’]tetraindole (CTet)" Molecules 15, no. 6: 4085-4093. https://doi.org/10.3390/molecules15064085

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