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Molecules 2010, 15(5), 3634-3642;

Synthesis and Effect on Human HepG2 Cells of 1,2-bis- (2-Methylallyl)disulfane

College of Chemistry and Chemical Engineering, Central South University, Changsha, Hunan 410083, China
Research Institute for Molecular Pharmacology and Therapeutics, Central South University, Changsha, Hunan 410083, China
Author to whom correspondence should be addressed.
Received: 16 April 2010 / Revised: 11 May 2010 / Accepted: 12 May 2010 / Published: 18 May 2010
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1,2-bis(2-methylallyl)disulfane was synthesized from sodium sulfide and 3-chloro-2-methylpropylene. The structure of the target product was confirmed by GC-MS, 1H-NMR and elemental analysis. Cell viability assay, flow-cytometric analysis and protein expression results showed that 1,2-bis(2-methylallyl)disulfane could significantly inhibit the proliferation, and induce the apoptosis of human HepG2 cells. View Full-Text
Keywords: 1,2-bis(2-methylallyl)disulfane; identification; apoptosis 1,2-bis(2-methylallyl)disulfane; identification; apoptosis

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Ji, C.; Ren, F.; Dai, J.; Xu, M. Synthesis and Effect on Human HepG2 Cells of 1,2-bis- (2-Methylallyl)disulfane. Molecules 2010, 15, 3634-3642.

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