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p-Aminoacetophenonic Acids Produced by a Mangrove Endophyte Streptomyces sp. (strain HK10552)

1
State Key Laboratory of Natural and Biomimetic Drugs, Peking University, Beijing 100191, China
2
School of Pharmaceutical Sciences, Shangxi Medical University, Shanxi 030001, China
3
Shanghai Center for Systems Biomedicine, Shanghai Jiaotong University, Shanghai 200240, China
4
Leibniz Institute for Natural Products Research and Infection Biology, Hans-Knöll Institute, Beutenbergstr.11a, D-07745 Jena, Germany
*
Authors to whom correspondence should be addressed.
Molecules 2010, 15(4), 2782-2790; https://doi.org/10.3390/molecules15042782
Received: 18 March 2010 / Revised: 31 March 2010 / Accepted: 6 April 2010 / Published: 16 April 2010
Four new p-aminoacetophenonic acids, named (2E)-11-(4′-aminophenyl)-5,9-dihydroxy-4,6,8-trimethyl-11-oxo-undec-2-enoic acid (1), 9-(4′-aminophenyl)-3,7-dihydroxy-2,4,6-trimethyl-9-oxo-nonoic acid(2), (2E)-11-(4′-aminophenyl)-5,9-O-cyclo-4,6,8-trimethyl-11-oxo-undec-2-enoic acid (3) and 9-(4′-aminophenyl)-3,7-O-cyclo-2,4,6-trimethyl-9-oxo-nonoic acid(4), were isolated from an endophyte Streptomyces sp. (strain HK10552) of the mangrove plant Aegiceras corniculatum. The structures of 14 were elucidated by using spectroscopic analyses. The relative stereoconfigurations of compounds 3 and 4 were determined by NOESY experiments. In the bioassay test, 14 showed no cytotoxicity against the Hela cell lines. Compound 4 also showed no inhibitory bioactivity on HCV protease and SecA ATPase and wasn’t active against VSVG/HIV-luc pseudotyping virus. View Full-Text
Keywords: p-aminoacetophenonic acids; endophyte; mangrove plant; Aegiceras corniculatum p-aminoacetophenonic acids; endophyte; mangrove plant; Aegiceras corniculatum
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Wang, F.; Xu, M.; Li, Q.; Sattler, I.; Lin, W. p-Aminoacetophenonic Acids Produced by a Mangrove Endophyte Streptomyces sp. (strain HK10552). Molecules 2010, 15, 2782-2790.

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