Glut1 and Glut3 as Potential Prognostic Markers for Oral Squamous Cell Carcinoma
Abstract
:1. Introduction
2. Results and Discussion
2.1. Patients’ Clinical Data
2.2. GLUT1 and GLUT3 Immunohistochemical Expression
2.3. GLUT 1 and GLUT 3: Immunoexpression and Clinical-Pathological Parameters
3. Experimental
3.1. Patients
3.2. Tissue microarray construction (TMA)
3.3. Immunohistochemistry
3.4. Evaluation of stained sections: GLUT1 and GLUT3
3.5. Statistical analysis
4. Conclusions
Acknowledgements
References
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Sample Availability: No samples are available. |
Varible | Group | Cases (%) |
---|---|---|
Gender (n = 142) | Male Female | 112 (78.9) 30 (21.1) |
Race (n = 142) | Caucasians Others | 122 (85.9) 20 (14.1) |
Tabacco (n = 142) | No Light Moderate/Severe Ignored | 15 (10.6) 99 (69.7) 17 (12) 11 (7.7) |
Alcohol (n = 142) | No Light Moderate/Severe Ignored | 27 (19.0) 89 (62.7) 15 (10.6) 11 (7.7) |
Site (n = 142) | Tongue Gingiva Floor of the mouth Palate Jugal Retromolar | 54 (38) 20 (14.1) 42 (29.6) 1 (0.7) 6 (4.2) 19 (13.4) |
Vascular Invision (n = 142) | No observed Yes Ignored | 75 (52.8) 53 (37.3) 14 (9.9) |
Clinic Stage (n = 142) | I/II III/IV | 37 (26.1) 105 (73.9) |
Recurrence (n = 142) | No Yes | 92 (64.8) 50 (35.2) |
Site of Recurrence (n = 142) | Local Others Local/others No recurrence | 41 (28.8) 7 (4.9) 2 (1.4) 92 (64.8) |
Status of last contact (n = 142) | Alive wth disease Alive wthout disease Death due to disease Death due to other causes Lost | 2 (1.4) 61 (43) 45 (31.7) 26 (18.3) 8 (5.6) |
Variable (n = 135) | Category | GLUT-1/grouping | ||||
---|---|---|---|---|---|---|
M | MN/N OR N | p | ||||
Gender | Male Female | 53(39.3) 15(11.1) | 54(40) 13(9.6) | 0.832 | ||
Alcohol | No Light Moderate/severe | 14(11.3) 37(29.8) 11(8.9) | 11(8.9) 48(38.7) 3(2.4) | 0.042 | ||
Staging | I/II III/IV | 19(14.1) 49(36.3) | 16(11.9) 51(37.8) | 0.695 | ||
Vascular Embolization | No yes | 31(25.6) 29(24) | 38(31.4) 23(19) | 0.273 |
Variable (n = 142) | Category | GLUT-3 | ||
---|---|---|---|---|
Positivo(%) | Negativo(%) | p | ||
Gender | Male Female | 87(61.3) 25(17.6) | 25(17.6) 5(3.5) | 0.619 |
Alcohol | No Light Moderate/severe | 3(2.3) 22(16.8) 3(2.3) | 24(18.3) 67(51.1) 12(9.2) | 0.316 |
Tabacco | No Light Moderate/severe | 1(0.8) 24(18.3) 3(2.3) | 14(10.7) 75(57.3) 14(10.7) | 0.279 |
Staging | I/II III/IV | 2(1,4) 28(19,7) | 35(24.6) 77(54.2) | 0.005 |
Vascular Embolization | No yes | 10(7,8) 19(14,8) | 65(50.8) 34(26.6) | 0.005 |
Variable | Category | HR (95% IC) | p valor |
---|---|---|---|
Vascular embolization | No | 1.0 (ref.) | |
Yes | 2.165 (1.295–3.618) | 0.003 | |
GLUT-1 | (group) | 1.0(ref.) | |
GLUT-1/pattern | (group 1) | 2.066( 1.232–3.464) | 0.006 |
GLUT-3 | Negative | 1.0 (ref.) | |
Positive | 1.933(1.119–3.339) | 0.018 |
Variable | Category | HR (95% IC) | p valor |
---|---|---|---|
staging | |||
I/II | 1.0 (ref.) | ||
III/IV | 3.304(1.407–7.762) | 0.006 |
© 2010 by the authors; licensee Molecular Diversity Preservation International, Basel, Switzerland. This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
Share and Cite
Ayala, F.R.R.; Rocha, R.M.; Carvalho, K.C.; Carvalho, A.L.; Da Cunha, I.W.; Lourenço, S.V.; Soares, F.A. Glut1 and Glut3 as Potential Prognostic Markers for Oral Squamous Cell Carcinoma. Molecules 2010, 15, 2374-2387. https://doi.org/10.3390/molecules15042374
Ayala FRR, Rocha RM, Carvalho KC, Carvalho AL, Da Cunha IW, Lourenço SV, Soares FA. Glut1 and Glut3 as Potential Prognostic Markers for Oral Squamous Cell Carcinoma. Molecules. 2010; 15(4):2374-2387. https://doi.org/10.3390/molecules15042374
Chicago/Turabian StyleAyala, Fernanda Rocha Rojas, Rafael Malagoli Rocha, Kátia Cândido Carvalho, André Lopes Carvalho, Isabela Werneck Da Cunha, Silvia Vanessa Lourenço, and Fernando Augusto Soares. 2010. "Glut1 and Glut3 as Potential Prognostic Markers for Oral Squamous Cell Carcinoma" Molecules 15, no. 4: 2374-2387. https://doi.org/10.3390/molecules15042374