Next Article in Journal
Catalytic Asymmetric Nitro-Mannich Reactions with a Yb/K Heterobimetallic Catalyst
Previous Article in Journal
Prodrug Approach for Increasing Cellular Glutathione Levels
Communication

Selective Growth Inhibitory Effect of Biochanin A Against Intestinal Tract Colonizing Bacteria

1
Department of Crop Sciences and Agroforestry, Institute of Tropics and Subtropics, Czech University of Life Sciences Prague, Kamycka 129, Prague 6, 165 21, Czech Republic
2
Department of Microbiology, Nutrition and Dietetics, Faculty of Agrobiology, Food and Natural Resources, Czech University of Life Sciences Prague, Kamycka 129, Prague 6, 165 21, Czech Republic
*
Author to whom correspondence should be addressed.
Molecules 2010, 15(3), 1270-1279; https://doi.org/10.3390/molecules15031270
Received: 13 January 2010 / Revised: 5 February 2010 / Accepted: 1 March 2010 / Published: 3 March 2010
Both bifidobacteria and clostridia are part of the natural gut microflora and while clostridia may be responsible for severe intestinal infections, bifidobacteria are probiotic microorganisms belonging to the most important prospective bacteria in the bowel. The antimicrobial activity of biochanin A was tested in vitro against six Bifidobacterium spp., and eight Clostridium spp. using the broth microdilution method. Biochanin A showed an inhibition against all clostridia in the range of minimum inhibitory concentrations (MIC) from 64 μg/mL (for Cl. clostridioforme, strains DSM 933 and I3) to 1,024 μg/mL (for Cl. perfringens, DSM 11778). No bifidobacteria were suppressed at four-fold higher concentration (MICs > 4,096) than MIC of Cl. perfringens. These results indicate selective growth inhibition of biochanin A and its potential use in antimicrobial prevention and/or protection. View Full-Text
Keywords: phytoestrogen; isoflavonoid; bifidobacteria; clostridia; selective antimicrobial activity phytoestrogen; isoflavonoid; bifidobacteria; clostridia; selective antimicrobial activity
Show Figures

Figure 1

MDPI and ACS Style

Sklenickova, O.; Flesar, J.; Kokoska, L.; Vlkova, E.; Halamova, K.; Malik, J. Selective Growth Inhibitory Effect of Biochanin A Against Intestinal Tract Colonizing Bacteria. Molecules 2010, 15, 1270-1279. https://doi.org/10.3390/molecules15031270

AMA Style

Sklenickova O, Flesar J, Kokoska L, Vlkova E, Halamova K, Malik J. Selective Growth Inhibitory Effect of Biochanin A Against Intestinal Tract Colonizing Bacteria. Molecules. 2010; 15(3):1270-1279. https://doi.org/10.3390/molecules15031270

Chicago/Turabian Style

Sklenickova, Olga, Jaroslav Flesar, Ladislav Kokoska, Eva Vlkova, Katerina Halamova, and Jan Malik. 2010. "Selective Growth Inhibitory Effect of Biochanin A Against Intestinal Tract Colonizing Bacteria" Molecules 15, no. 3: 1270-1279. https://doi.org/10.3390/molecules15031270

Find Other Styles

Article Access Map by Country/Region

1
Only visits after 24 November 2015 are recorded.
Back to TopTop