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Synthesis and Anti-Bacterial Activities of Some Novel Schiff Bases Derived from Aminophenazone

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Chemistry Department, Faculty of Science, King Abdul Aziz University, P.O. Box 80203, Jeddah 21589, Saudi Arabia
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The Center of Excellence for Advanced Materials, King Abdul Aziz University, Jeddah 21589, P.O. Box 80203, Saudi Arabia
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Author to whom correspondence should be addressed.
Molecules 2010, 15(10), 6850-6858; https://doi.org/10.3390/molecules15106850
Received: 20 July 2010 / Revised: 16 August 2010 / Accepted: 18 August 2010 / Published: 8 October 2010
A series of 1,5-dimethyl-2-phenyl-1,2-dihydro-3H-pyrazol-3-one-containing Schiff bases were synthesized, characterized and screened for their antibacterial activities. The structures of the synthesized compounds were established by spectroscopic (FT-IR, 1H-NMR, 13C-NMR, MS) and elemental analyses. The anti-bacterial activities (with MIC values) of compounds were evaluated. The anti-bacterial screening results reveal that among the six compounds screened, four compounds showed moderate to good anti-bacterial activity. Among the tested compounds, the most effective compounds against four bacterial strains, viz. Escherichia coli, Staphylococcus aureus, Salmonella typhimurium and Streptococcus pyogenes, are [(2-Chlorobenzylidene)amino]-1,5-dimethyl-2-phenyl-1,2-dihydropyrazol-3-one (4) and [(1,5-Dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-ylimino)methyl]benzonitrile (5) with MIC values of 6.25 μg/mL. View Full-Text
Keywords: Schiff bases; aminophenazone; antibacterial activity; ciprofloxacin Schiff bases; aminophenazone; antibacterial activity; ciprofloxacin
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MDPI and ACS Style

Asiri, A.M.; Khan, S.A. Synthesis and Anti-Bacterial Activities of Some Novel Schiff Bases Derived from Aminophenazone. Molecules 2010, 15, 6850-6858. https://doi.org/10.3390/molecules15106850

AMA Style

Asiri AM, Khan SA. Synthesis and Anti-Bacterial Activities of Some Novel Schiff Bases Derived from Aminophenazone. Molecules. 2010; 15(10):6850-6858. https://doi.org/10.3390/molecules15106850

Chicago/Turabian Style

Asiri, Abdullah M., and Salman A Khan. 2010. "Synthesis and Anti-Bacterial Activities of Some Novel Schiff Bases Derived from Aminophenazone" Molecules 15, no. 10: 6850-6858. https://doi.org/10.3390/molecules15106850

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