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2β-(Isobutyryloxy)florilenalin, a Sesquiterpene Lactone Isolated from the Medicinal Plant Centipeda minima, Induces Apoptosis in Human Nasopharyngeal Carcinoma CNE Cells

by Miaoxian Su 1, Yaolan Li 2,3, Hau Yin Chung 1,4,* and Wencai Ye 2,3
1
Department of Biology, The Chinese University of Hong Kong, Hong Kong, China
2
Institute of Traditional Chinese Medicine & Natural Products, College of Pharmacy, Jinan University, Guangzhou 510632, China
3
Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drug Research, Guangzhou 510632, China
4
Food and Nutritional Sciences Programme, The Chinese University of Hong Kong, Hong Kong, China
*
Author to whom correspondence should be addressed.
Molecules 2009, 14(6), 2135-2146; https://doi.org/10.3390/molecules14062135
Received: 10 April 2009 / Revised: 12 May 2009 / Accepted: 2 June 2009 / Published: 12 June 2009
Centipeda minima is a medicinal plant reputed in China as a remedy for nasopharyngeal carcinoma (NPC). In this study, bioactivity-guided fractionation of the anti-NPC compound(s) from C. minima led to the isolation of 2β-(isobutyryloxy)florilenalin (IF), a sesquiterpene lactone. IF showed significant dose- and time- dependent inhibition on the growth of the human nasopharyngeal carcinoma epithelia cells (CNE). It induced apoptosis in CNE cells, as shown by the accumulation of sub-G1 cell population, DNA fragmentation and nuclear condensation, caspase-3 activation and PARP cleavage. Such induction was associated with the depletion of mitochondrial membrane potential (ΔΨm) and the release of cytochrome c to cytosol to regulate the expression of Bcl-2 family proteins. These activities led to the cleavage of caspases and the trigger of cell death process. Overall, IF in C. minima showed potent antiproliferative effect of C. minima on NPC cells, suggesting that the plant deserves more extensive investigation for its potential medicinal application. View Full-Text
Keywords: 2-β(isobutyryloxy)florilenalin; centipeda minima; sesquiterpene lactone; apoptosis; nasopharyngeal carcinoma 2-β(isobutyryloxy)florilenalin; centipeda minima; sesquiterpene lactone; apoptosis; nasopharyngeal carcinoma
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Su, M.; Li, Y.; Chung, H.Y.; Ye, W. 2β-(Isobutyryloxy)florilenalin, a Sesquiterpene Lactone Isolated from the Medicinal Plant Centipeda minima, Induces Apoptosis in Human Nasopharyngeal Carcinoma CNE Cells. Molecules 2009, 14, 2135-2146.

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