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Cytotoxic Components of Pereskia bleo (Kunth) DC. (Cactaceae) Leaves

1
Institute of Biological Sciences, Faculty of Science, University of Malaya, 50603 Kuala Lumpur, Malaysia
2
Institute of Postgraduate Studies, University of Malaya, 50603 Kuala Lumpur, Malaysia
3
International University College of Nursing, B-27-6, Block B, Jaya One, No 72A Jalan Universiti, 46000 Petaling Jaya, Selangor, Malaysia
*
Author to whom correspondence should be addressed.
Molecules 2009, 14(5), 1713-1724; https://doi.org/10.3390/molecules14051713
Received: 17 March 2009 / Revised: 7 April 2009 / Accepted: 4 May 2009 / Published: 6 May 2009
Dihydroactinidiolide (1) and a mixture of sterols [campesterol (2), stigmasterol (3) and β-sitosterol (4)], together with the previously isolated individual compounds β-sitosterol (4), 2,4-di-tert-butylphenol (5), α-tocopherol (6), phytol (7) were isolated from the active ethyl acetate fraction of Pereskia bleo (Kunth) DC. (Cactaceae) leaves. Cytotoxic activities of the above mentioned compounds against five human carcinoma cell lines, namely the human nasopharyngeal epidermoid carcinoma cell line (KB), human cervical carcinoma cell line (CasKi), human colon carcinoma cell line (HCT 116), human hormone-dependent breast carcinoma cell line (MCF7) and human lung carcinoma cell line (A549); and non-cancer human fibroblast cell line (MRC-5) were investigated. Compound 5 possessed very remarkable cytotoxic activity against KB cells, with an IC50 value of 0.81µg/mL. This is the first report on the cytotoxic activities of the compounds isolated from Pereskia bleo. View Full-Text
Keywords: Pereskia bleo; Cactaceae; cytotoxic activity; cell lines Pereskia bleo; Cactaceae; cytotoxic activity; cell lines
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Malek, S.N.A.; Shin, S.K.; Wahab, N.A.; Yaacob, H. Cytotoxic Components of Pereskia bleo (Kunth) DC. (Cactaceae) Leaves. Molecules 2009, 14, 1713-1724.

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