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Open AccessArticle

Antimalarial Activity of Ultra-Short Peptides

1
Centro de Investigaciones Químicas, Universidad Autónoma del Estado de Morelos, Avenida Universidad 1001, Col. Chamilpa, 62209 Cuernavaca, Morelos, México
2
Instituto Nacional de Salud Pública, Centro de Investigación Sobre Enfermedades Infecciosas (CISEI), Avenida Universidad 655, Col. Santa María Ahuacatitlán, 62100 Cuernavaca, Morelos, México
*
Author to whom correspondence should be addressed.
This paper is taken in part from the Ph.D. thesis of Lemuel Pérez-Picaso.
Molecules 2009, 14(12), 5103-5114; https://doi.org/10.3390/molecules14125103
Received: 18 November 2009 / Revised: 8 December 2009 / Accepted: 8 December 2009 / Published: 8 December 2009
Ultra-short peptides 1-9 were designed and synthesized with phenylalanine, ornithine and proline amino acid residues and their effect on antimalarial activity was analyzed. On the basis of the IC50 data for these compounds, the effects of nature, polarity, and amino acid sequence on Plasmodium berghei schizont cultures were analyzed too. Tetrapeptides Phe-Orn-Phe-Orn (4) and Lys-Phe-Phe-Orn (5) showed a very important activity with IC50 values of 3.31 and 2.57 μM, respectively. These two tetrapeptides are candidates for subsequent in vivo assays and SARS investigations. View Full-Text
Keywords: tetrapeptides; antimalarial activity; Plasmodium berghei; ultra-short peptides tetrapeptides; antimalarial activity; Plasmodium berghei; ultra-short peptides
MDPI and ACS Style

Pérez-Picaso, L.; Velasco-Bejarano, B.; Aguilar-Guadarrama, A.B.; Argotte-Ramos, R.; Rios, M.Y. Antimalarial Activity of Ultra-Short Peptides. Molecules 2009, 14, 5103-5114.

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