Next Article in Journal
Calpain Inhibition Reduces Axolemmal Leakage in Traumatic Axonal Injury
Previous Article in Journal
Neuroprotection by Radical Avoidance: Search for Suitable Agents
Open AccessArticle

Antimalarial Activity of Ultra-Short Peptides

Centro de Investigaciones Químicas, Universidad Autónoma del Estado de Morelos, Avenida Universidad 1001, Col. Chamilpa, 62209 Cuernavaca, Morelos, México
Instituto Nacional de Salud Pública, Centro de Investigación Sobre Enfermedades Infecciosas (CISEI), Avenida Universidad 655, Col. Santa María Ahuacatitlán, 62100 Cuernavaca, Morelos, México
Author to whom correspondence should be addressed.
This paper is taken in part from the Ph.D. thesis of Lemuel Pérez-Picaso.
Molecules 2009, 14(12), 5103-5114;
Received: 18 November 2009 / Revised: 8 December 2009 / Accepted: 8 December 2009 / Published: 8 December 2009
Ultra-short peptides 1-9 were designed and synthesized with phenylalanine, ornithine and proline amino acid residues and their effect on antimalarial activity was analyzed. On the basis of the IC50 data for these compounds, the effects of nature, polarity, and amino acid sequence on Plasmodium berghei schizont cultures were analyzed too. Tetrapeptides Phe-Orn-Phe-Orn (4) and Lys-Phe-Phe-Orn (5) showed a very important activity with IC50 values of 3.31 and 2.57 μM, respectively. These two tetrapeptides are candidates for subsequent in vivo assays and SARS investigations. View Full-Text
Keywords: tetrapeptides; antimalarial activity; Plasmodium berghei; ultra-short peptides tetrapeptides; antimalarial activity; Plasmodium berghei; ultra-short peptides
MDPI and ACS Style

Pérez-Picaso, L.; Velasco-Bejarano, B.; Aguilar-Guadarrama, A.B.; Argotte-Ramos, R.; Rios, M.Y. Antimalarial Activity of Ultra-Short Peptides. Molecules 2009, 14, 5103-5114.

Show more citation formats Show less citations formats

Article Access Map by Country/Region

Only visits after 24 November 2015 are recorded.
Search more from Scilit
Back to TopTop