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Molecules 2007, 12(4), 896-906;

4'-Acetamidochalcone Derivatives as Potential Antinociceptive Agents

Núcleo de Investigações Químico-Farmacêuticas (NIQFAR)/CCS, Universidade do Vale do Itajaí (UNIVALI), Itajaí-SC, Brazil
Departamento de Química, Universidade Federal de Santa Catarina (UFSC), Florianópolis-SC, Brazil
Author to whom correspondence should be addressed.
Received: 22 March 2007 / Revised: 22 April 2007 / Accepted: 24 April 2007 / Published: 30 April 2007
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Nine acetamidochalcones were synthesized and evaluated as antinociceptive agents using the mice writhing test. Given intraperitoneally all the compounds were more effective than the two reference analgesic drugs (acetylsalicylic acid and acetaminophen) used for comparison. N-{4-[(2E)-3-(4-nitrophenyl)prop-2-enoyl]phenyl}acetamide (6) was the most effective compound and was therefore selected for more detailed studies. It caused dose-related inhibition in the writhing test, being about 32 to 34-fold more potent than the standard drugs. It was also effective in the second phase of the formalin test and the capsaicin test. These acetamidochalcones, especially compound 6, might be further used as models to obtain new and more potent analgesic drugs. View Full-Text
Keywords: Acetamidochalcones; antinociception; mice Acetamidochalcones; antinociception; mice

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De Campos-Buzzi, F.; Padaratz, P.; Meira, A.V.; Corrêa, R.; Nunes, R.J.; Cechinel-Filho, V. 4'-Acetamidochalcone Derivatives as Potential Antinociceptive Agents. Molecules 2007, 12, 896-906.

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