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Retraction published on 10 September 2007, see Molecules 2007, 12(9), 2160.

Open AccessArticle
Molecules 2007, 12(3), 673-678;

Synthesis of Gefitinibfrom Methyl 3-Hydroxy-4-methoxy-benzoate

Institute of Pharmaceutical Engineering, School of Chemistry and Chemical Engineering, Jiangsu Laboratory for Biomaterials and Devices, Southeast University, 210096 Nanjing, P. R. China
Author to whom correspondence should be addressed.
Received: 9 March 2007 / Revised: 22 March 2007 / Accepted: 23 March 2007 / Published: 28 March 2007
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This paper reports a novel synthesis of gefitinib starting from methyl3-hydroxy-4-methoxybenzoate. The process starts with alkylation of the starting material, followed by nitration, reduction, cyclization, chlorination and two successive amination reactions. The intermediates andtarget molecule were characterized by 1H-NMR, 13C-NMR, MSand the purities of all these compounds were determined by HPLC. This novelsynthetic route produced overall yields as high as 37.4%. View Full-Text
Keywords: Gefitinib; tyrosine kinase inhibitors; methyl 3-hydroxy-4-methoxybenzoate Gefitinib; tyrosine kinase inhibitors; methyl 3-hydroxy-4-methoxybenzoate

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This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

Li, M.D.; Zheng, Y.G.; Ji, M. Synthesis of Gefitinibfrom Methyl 3-Hydroxy-4-methoxy-benzoate. Molecules 2007, 12, 673-678.

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