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Synthesis and Antiviral Bioactivities of α-Aminophosphonates Containing Alkoxyethyl Moieties

1
Center for Research and Development of Fine Chemicals, Guizhou University, Key Laboratory of Green Pesticide and Agricultural Bioengineering, Ministry of Education, Guiyang, 550025, P. R. China
2
Laboratory of Medicinal Chemistry, Zunyi, Medical College, 563003, Zunyi, P. R. China
*
Author to whom correspondence should be addressed.
Molecules 2006, 11(9), 666-676; https://doi.org/10.3390/11090666
Received: 9 August 2006 / Revised: 5 September 2006 / Accepted: 5 September 2006 / Published: 6 September 2006
A simple, efficient, and general method has been developed for the synthesis ofvarious α-aminophosphonate derivatives 4a-4l by treatment of substituted benzaldehydes andaniline with bis(2-methoxyethyl)- or bis(2-ethoxyethyl) phosphite under microwaveirradiation without solvents and catalysts. The products were characterized by elementalanalysis, IR, 1H-NMR, 13C- and 31P-NMR spectra. The X-ray crystallographic data of therepresentative compound 4l was determined. The new α-aminophosphonate derivatives werefound to possess moderate to good antiviral activity. View Full-Text
Keywords: Aminophosphonates; microwave irradiation; synthesis; antiviral activity Aminophosphonates; microwave irradiation; synthesis; antiviral activity
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MDPI and ACS Style

Xu, Y.; Yan, K.; Song, B.; Xu, G.; Yang, S.; Xue, W.; Hu, D.; Lu, P.; Ouyang, G.; Jin, L.; Chen, Z. Synthesis and Antiviral Bioactivities of α-Aminophosphonates Containing Alkoxyethyl Moieties. Molecules 2006, 11, 666-676. https://doi.org/10.3390/11090666

AMA Style

Xu Y, Yan K, Song B, Xu G, Yang S, Xue W, Hu D, Lu P, Ouyang G, Jin L, Chen Z. Synthesis and Antiviral Bioactivities of α-Aminophosphonates Containing Alkoxyethyl Moieties. Molecules. 2006; 11(9):666-676. https://doi.org/10.3390/11090666

Chicago/Turabian Style

Xu, Yingshu, Kai Yan, Baoan Song, Gangfang Xu, Song Yang, Wei Xue, Deyu Hu, Ping Lu, Guiping Ouyang, Linhong Jin, and Zhuo Chen. 2006. "Synthesis and Antiviral Bioactivities of α-Aminophosphonates Containing Alkoxyethyl Moieties" Molecules 11, no. 9: 666-676. https://doi.org/10.3390/11090666

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