Next Article in Journal
Hydantoin Derivatives of L- and D-amino acids: Synthesis and Evaluation of Their Antiviral and Antitumoral Activity
Previous Article in Journal
Highly Volatile Constituents of Vetiveria zizanioides Roots Grown under Different Cultivation Conditions
Article Menu

Export Article

Open AccessArticle
Molecules 2006, 11(11), 827-836;

Regioselective Synthesis of Novel N2- and N4-Substituted 7-Methylpyrazolo[4,5-e][1,2,4]thiadiazines

Institute of Medicinal Chemistry, School of Pharmacy, Shandong University, Jinan 250012, P.R. China
Instituto de Quimica Medica (CSIC), c/Juan de la Cierva, 3, 28006 Madrid, Spain
Author to whom correspondence should be addressed.
Received: 5 October 2006 / Revised: 22 October 2006 / Accepted: 23 October 2006 / Published: 1 November 2006
Full-Text   |   PDF [104 KB, uploaded 18 June 2014]   |  


The new compound 7-methylpyrazolo[4,5-e][1,2,4]thiadiazin-3(2H,4H)-one1,1-dioxide (5) was synthesized and its novel mono N2- or N4-substituted derivatives 6and 7 were prepared by regioselective N-alkylation of 5 with different molar ratios ofNaH and alkyl halides. Based on the regioselective alkylation conditions found a facileone-pot synthesis of N2,N4-disubstituted pyrazolo[4,5-e][1,2,4] thiadiazines 8 wasdeveloped. The structures of the newly synthesized compounds were confirmed by IR,1H-NMR, 13C-NMR and MS spectral analysis. View Full-Text
Keywords: Pyrazolothiadiazines; regioselectivity; synthesis; alkylation; one-pot reaction Pyrazolothiadiazines; regioselectivity; synthesis; alkylation; one-pot reaction

Figure 1

This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

Share & Cite This Article

MDPI and ACS Style

Liu, X.; Yan, R.; Chen, N.; Xu, W.; Molina, M.T.; Vega, S. Regioselective Synthesis of Novel N2- and N4-Substituted 7-Methylpyrazolo[4,5-e][1,2,4]thiadiazines. Molecules 2006, 11, 827-836.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics



[Return to top]
Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top