Deadline for manuscript submissions: closed (30 April 2010)
Special Issue Editor
Guest Editor Dr. C. Chris Yun
Emory University, School of Medicine, Division of Digestive Diseases, Whitehead Bldg., Suite 201, 615 Michael St. Atlanta, GA 30322, USA
Website: http://medicine.emory.edu/digestive-diseases/labs/yun-lab/index.html Phone: +1 404 712 2865 Fax: +1 404 727 5767 Interests: effects of lysophosphoipids in colon cancer and colitis; sodium and fluid absorption in the intestine and kidney; protein-protein interaction; chemokine sin colon cancer; cancer therapeutics; GPCR signaling
Special Issue Information
Enterotoxins elicit their primary effects in the intestinal tract, initiating a metabolic cascade that results in excessive fluid and electrolyte secretion. Enterotoxins are frequently cytotoxic and kill cells by altering the apical membrane permeability of the mucosal epithelial cells of the intestinal wall. The uniform host response is the development of diarrhea. However, at a cellular level and subcellular level, certain enterotoxins induce sophisticated and fascinating metabolic alterations, which can affect the local immune system in a characteristic fashion. In some cases, enterotoxins induce disease outside the gastrointestinal tract, affecting other organ systems. Enterotoxins can exert diverse effects at the same time, either inducing or suppressing the immune cascade. This special issue of Toxins deals with major achievement and recent advances in enterotoxin secretion, toxin trafficking, toxin recognition, host interaction, and disease progression.