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Toxins 2010, 2(7), 1913-1927; doi:10.3390/toxins2071913
Review

NetB, a Pore-Forming Toxin from Necrotic Enteritis Strains of Clostridium perfringens

1
,
2
,
1,2
 and
2,*
1 CSIRO Livestock Industries, Australian Animal Health Laboratory, Geelong, Victoria 3220, Australia 2 Australian Research Council Centre of Excellence in Structural and Functional Microbial Genomics, Department of Microbiology, Monash University, Victoria 3800, Australia
* Author to whom correspondence should be addressed.
Received: 22 June 2010 / Revised: 9 July 2010 / Accepted: 22 July 2010 / Published: 23 July 2010
(This article belongs to the Special Issue Enterotoxins)
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Abstract

The Clostridium perfringens necrotic enteritis B-like toxin (NetB) is a recently discovered member of the β-barrel pore-forming toxin family and is produced by a subset of avian C. perfringens type A strains. NetB is cytotoxic for avian cells and is associated with avian necrotic enteritis. This review examines the current state of knowledge of NetB: its role in pathogenesis, its distribution and expression in C. perfringens and its vaccine potential.
Keywords: NetB; necrotic enteritis; Clostridium perfringens; pore-forming toxin NetB; necrotic enteritis; Clostridium perfringens; pore-forming toxin
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).
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Keyburn, A.L.; Bannam, T.L.; Moore, R.J.; Rood, J.I. NetB, a Pore-Forming Toxin from Necrotic Enteritis Strains of Clostridium perfringens. Toxins 2010, 2, 1913-1927.

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