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NetB, a Pore-Forming Toxin from Necrotic Enteritis Strains of Clostridium perfringens
CSIRO Livestock Industries, Australian Animal Health Laboratory, Geelong, Victoria 3220, Australia
Australian Research Council Centre of Excellence in Structural and Functional Microbial Genomics, Department of Microbiology, Monash University, Victoria 3800, Australia
* Author to whom correspondence should be addressed.
Received: 22 June 2010; in revised form: 9 July 2010 / Accepted: 22 July 2010 / Published: 23 July 2010
Abstract: The Clostridium perfringens necrotic enteritis B-like toxin (NetB) is a recently discovered member of the β-barrel pore-forming toxin family and is produced by a subset of avian C. perfringens type A strains. NetB is cytotoxic for avian cells and is associated with avian necrotic enteritis. This review examines the current state of knowledge of NetB: its role in pathogenesis, its distribution and expression in C. perfringens and its vaccine potential.
Keywords: NetB; necrotic enteritis; Clostridium perfringens; pore-forming toxin
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Keyburn, A.L.; Bannam, T.L.; Moore, R.J.; Rood, J.I. NetB, a Pore-Forming Toxin from Necrotic Enteritis Strains of Clostridium perfringens. Toxins 2010, 2, 1913-1927.
Keyburn AL, Bannam TL, Moore RJ, Rood JI. NetB, a Pore-Forming Toxin from Necrotic Enteritis Strains of Clostridium perfringens. Toxins. 2010; 2(7):1913-1927.
Keyburn, Anthony L.; Bannam, Trudi L.; Moore, Robert J.; Rood, Julian I. 2010. "NetB, a Pore-Forming Toxin from Necrotic Enteritis Strains of Clostridium perfringens." Toxins 2, no. 7: 1913-1927.