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Toxins 2010, 2(7), 1913-1927; doi:10.3390/toxins2071913
Review

NetB, a Pore-Forming Toxin from Necrotic Enteritis Strains of Clostridium perfringens

1
, 2
, 1,2
 and 2,*
1 CSIRO Livestock Industries, Australian Animal Health Laboratory, Geelong, Victoria 3220, Australia 2 Australian Research Council Centre of Excellence in Structural and Functional Microbial Genomics, Department of Microbiology, Monash University, Victoria 3800, Australia
* Author to whom correspondence should be addressed.
Received: 22 June 2010 / Revised: 9 July 2010 / Accepted: 22 July 2010 / Published: 23 July 2010
(This article belongs to the Special Issue Enterotoxins)
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Abstract

The Clostridium perfringens necrotic enteritis B-like toxin (NetB) is a recently discovered member of the β-barrel pore-forming toxin family and is produced by a subset of avian C. perfringens type A strains. NetB is cytotoxic for avian cells and is associated with avian necrotic enteritis. This review examines the current state of knowledge of NetB: its role in pathogenesis, its distribution and expression in C. perfringens and its vaccine potential.
Keywords: NetB; necrotic enteritis; Clostridium perfringens; pore-forming toxin NetB; necrotic enteritis; Clostridium perfringens; pore-forming toxin
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Keyburn, A.L.; Bannam, T.L.; Moore, R.J.; Rood, J.I. NetB, a Pore-Forming Toxin from Necrotic Enteritis Strains of Clostridium perfringens. Toxins 2010, 2, 1913-1927.

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