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Toxins 2010, 2(6), 1336-1356; doi:10.3390/toxins2061336
Review

On the Interaction of Clostridium perfringens Enterotoxin with Claudins

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Received: 5 May 2010; in revised form: 21 May 2010 / Accepted: 4 June 2010 / Published: 8 June 2010
(This article belongs to the Special Issue Enterotoxins)
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Abstract: Clostridium perfringens causes one of the most common foodborne illnesses, which is largely mediated by the Clostridium perfringens enterotoxin (CPE). The toxin consists of two functional domains. The N-terminal region mediates the cytotoxic effect through pore formation in the plasma membrane of the mammalian host cell. The C-terminal region (cCPE) binds to the second extracellular loop of a subset of claudins. Claudin-3 and claudin-4 have been shown to be receptors for CPE with very high affinity. The toxin binds with weak affinity to claudin-1 and -2 but contribution of these weak binding claudins to CPE-mediated disease is questionable. cCPE is not cytotoxic, however, it is a potent modulator of tight junctions. This review describes recent progress in the molecular characterization of the cCPE-claudin interaction using mutagenesis, in vitro binding assays and permeation studies. The results promote the development of recombinant cCPE-proteins and CPE-based peptidomimetics to modulate tight junctions for improved drug delivery or to treat tumors overexpressing claudins.
Keywords: Claudins; Clostridium perfringens enterotoxin; drug delivery; tight junction Claudins; Clostridium perfringens enterotoxin; drug delivery; tight junction
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Veshnyakova, A.; Protze, J.; Rossa, J.; Blasig, I.E.; Krause, G.; Piontek, J. On the Interaction of Clostridium perfringens Enterotoxin with Claudins. Toxins 2010, 2, 1336-1356.

AMA Style

Veshnyakova A, Protze J, Rossa J, Blasig IE, Krause G, Piontek J. On the Interaction of Clostridium perfringens Enterotoxin with Claudins. Toxins. 2010; 2(6):1336-1356.

Chicago/Turabian Style

Veshnyakova, Anna; Protze, Jonas; Rossa, Jan; Blasig, Ingolf E.; Krause, Gerd; Piontek, Joerg. 2010. "On the Interaction of Clostridium perfringens Enterotoxin with Claudins." Toxins 2, no. 6: 1336-1356.


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