Next Article in Journal / Special Issue
Different Types of Cell Death Induced by Enterotoxins
Previous Article in Journal / Special Issue
Multiple Roles of Staphylococcus aureus Enterotoxins: Pathogenicity, Superantigenic Activity, and Correlation to Antibiotic Resistance
Article Menu

Export Article

Open AccessReview
Toxins 2010, 2(8), 2132-2157; doi:10.3390/toxins2082132

Toxin Mediated Diarrhea in the 21st Century: The Pathophysiology of Intestinal Ion Transport in the Course of ETEC, V. cholerae and Rotavirus Infection

Departments of Surgery & Cellular and Molecular Physiology, Yale University School of Medicine, New Haven, CT, USA
*
Author to whom correspondence should be addressed.
Received: 23 June 2010 / Accepted: 9 August 2010 / Published: 10 August 2010
(This article belongs to the Special Issue Enterotoxins)
View Full-Text   |   Download PDF [391 KB, uploaded 10 August 2010]   |  

Abstract

An estimated 4 billion episodes of diarrhea occur each year. As a result, 2–3 million children and 0.5–1 million adults succumb to the consequences of this major healthcare concern. The majority of these deaths can be attributed to toxin mediated diarrhea by infectious agents, such as E. coli, V. cholerae or Rotavirus. Our understanding of the pathophysiological processes underlying these infectious diseases has notably improved over the last years. This review will focus on the cellular mechanism of action of the most common enterotoxins and the latest specific therapeutic approaches that have been developed to contain their lethal effects.
Keywords: cholera; enterotoxigenic E. coli; enterotoxin; NSP4; STa; LT-I cholera; enterotoxigenic E. coli; enterotoxin; NSP4; STa; LT-I
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Kopic, S.; Geibel, J.P. Toxin Mediated Diarrhea in the 21st Century: The Pathophysiology of Intestinal Ion Transport in the Course of ETEC, V. cholerae and Rotavirus Infection. Toxins 2010, 2, 2132-2157.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Toxins EISSN 2072-6651 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top