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Cure and Curse: E. coli Heat-Stable Enterotoxin and Its Receptor Guanylyl Cyclase C
Lehrstuhl für Biopolymere und Forschungszentrum für Bio-Makromoleküle, Universität Bayreuth, Universitätsstraße 30, 95447 Bayreuth, Germany
* Author to whom correspondence should be addressed.
Received: 15 July 2010; in revised form: 12 August 2010 / Accepted: 24 August 2010 / Published: 26 August 2010
Abstract: Enterotoxigenic Escherichia coli (ETEC) associated diarrhea is responsible for roughly half a million deaths per year, the majority taking place in developing countries. The main agent responsible for these diseases is the bacterial heat-stable enterotoxin STa. STa is secreted by ETEC and after secretion binds to the intestinal receptor guanylyl cyclase C (GC-C), thus triggering a signaling cascade that eventually leads to the release of electrolytes and water in the intestine. Additionally, GC-C is a specific marker for colorectal carcinoma and STa is suggested to have an inhibitory effect on intestinal carcinogenesis. To understand the conformational events involved in ligand binding to GC-C and to devise therapeutic strategies to treat both diarrheal diseases and colorectal cancer, it is paramount to obtain structural information on the receptor ligand system. Here we summarize the currently available structural data and report on physiological consequences of STa binding to GC-C in intestinal epithelia and colorectal carcinoma cells.
Keywords: heat-stable enterotoxin; guanylyl cyclase C; secretory diarrhea; colorectal cancer
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Weiglmeier, P.R.; Rösch, P.; Berkner, H. Cure and Curse: E. coli Heat-Stable Enterotoxin and Its Receptor Guanylyl Cyclase C. Toxins 2010, 2, 2213-2229.
Weiglmeier PR, Rösch P, Berkner H. Cure and Curse: E. coli Heat-Stable Enterotoxin and Its Receptor Guanylyl Cyclase C. Toxins. 2010; 2(9):2213-2229.
Weiglmeier, Philipp R.; Rösch, Paul; Berkner, Hanna. 2010. "Cure and Curse: E. coli Heat-Stable Enterotoxin and Its Receptor Guanylyl Cyclase C." Toxins 2, no. 9: 2213-2229.