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Toxins 2010, 2(7), 1704-1717; doi:10.3390/toxins2071704
Article

Uncoupling of T Cell Receptor Zeta Chain Function during the Induction of Anergy by the Superantigen, Staphylococcal Enterotoxin A

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Received: 5 May 2010 / Revised: 17 June 2010 / Accepted: 28 June 2010 / Published: 30 June 2010
(This article belongs to the Special Issue Enterotoxins)
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Abstract

Staphylococcus aureus enterotoxins have immunomodulatory properties. In this study, we show that Staphylococcal enterotoxin A (SEA) induces a strong proliferative response in a murine T cell clone independent of MHC class II bearing cells. SEA stimulation also induces a state of hypo-responsiveness (anergy). We characterized the components of the T cell receptor (TCR) during induction of anergy by SEA. Most interestingly, TCR zeta chain phosphorylation was absent under SEA anergizing conditions, which suggests an uncoupling of zeta chain function. We characterize here a model system for studying anergy in the absence of confounding costimulatory signals.
Keywords: superantigen; Staphylococcus aureus; SEA; anergy; zeta chain; enterotoxin superantigen; Staphylococcus aureus; SEA; anergy; zeta chain; enterotoxin
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Cornwell, W.D.; Rogers, T.J. Uncoupling of T Cell Receptor Zeta Chain Function during the Induction of Anergy by the Superantigen, Staphylococcal Enterotoxin A. Toxins 2010, 2, 1704-1717.

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