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Toxins 2010, 2(7), 1704-1717; doi:10.3390/toxins2071704
Article
Uncoupling of T Cell Receptor Zeta Chain Function during the Induction of Anergy by the Superantigen, Staphylococcal Enterotoxin A
FELS Institute, Temple University School of Medicine, 3307 North Broad Street, Philadelphia, PA 19140, USA
* Author to whom correspondence should be addressed.
Received: 5 May 2010; in revised form: 17 June 2010 / Accepted: 28 June 2010 / Published: 30 June 2010
(This article belongs to the Special Issue Enterotoxins)
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Abstract: Staphylococcus aureus enterotoxins have immunomodulatory properties. In this study, we show that Staphylococcal enterotoxin A (SEA) induces a strong proliferative response in a murine T cell clone independent of MHC class II bearing cells. SEA stimulation also induces a state of hypo-responsiveness (anergy). We characterized the components of the T cell receptor (TCR) during induction of anergy by SEA. Most interestingly, TCR zeta chain phosphorylation was absent under SEA anergizing conditions, which suggests an uncoupling of zeta chain function. We characterize here a model system for studying anergy in the absence of confounding costimulatory signals.
Keywords: superantigen; Staphylococcus aureus; SEA; anergy; zeta chain; enterotoxin
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MDPI and ACS Style
Cornwell, W.D.; Rogers, T.J. Uncoupling of T Cell Receptor Zeta Chain Function during the Induction of Anergy by the Superantigen, Staphylococcal Enterotoxin A. Toxins 2010, 2, 1704-1717.
AMA StyleCornwell WD, Rogers TJ. Uncoupling of T Cell Receptor Zeta Chain Function during the Induction of Anergy by the Superantigen, Staphylococcal Enterotoxin A. Toxins. 2010; 2(7):1704-1717.
Chicago/Turabian StyleCornwell, William D.; Rogers, Thomas J. 2010. "Uncoupling of T Cell Receptor Zeta Chain Function during the Induction of Anergy by the Superantigen, Staphylococcal Enterotoxin A." Toxins 2, no. 7: 1704-1717.