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Toxins 2010, 2(5), 954-962; doi:10.3390/toxins2050954
Review

The Role of Lymphostatin/EHEC Factor for Adherence-1 in the Pathogenesis of Gram Negative Infection

Division of Digestive Diseases, Emory University, Atlanta GA 30322, USA
Received: 21 March 2010 / Revised: 22 April 2010 / Accepted: 27 April 2010 / Published: 5 May 2010
(This article belongs to the Special Issue Enterotoxins)
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Abstract

Lymphostatin/EHEC factor for adherence-1 is a novel large toxin represented in various Gram negative bacteria, highly associated with the development of infectious diarrhea and hemolytic uremic syndrome. In vitro and in vivo experiments identified lymphostatin/EFA-1 as a toxin with a central role in the pathogenesis of Gram negative bacteria, responsible for bacterial adhesion, intestinal colonization, immunosuppression, and disruption of gut epithelial barrier function.
Keywords: lymphocyte inhibitory factor A/EHEC factor for adherence-1; lymphostatin; Gram negative bacterial toxin; Enteropathogenic E. coli; Enterohemorrhagic E. coli; immunosuppression; Citrobacter rodentium; intestinal epithelial barrier function lymphocyte inhibitory factor A/EHEC factor for adherence-1; lymphostatin; Gram negative bacterial toxin; Enteropathogenic E. coli; Enterohemorrhagic E. coli; immunosuppression; Citrobacter rodentium; intestinal epithelial barrier function
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Klapproth, J.-M. The Role of Lymphostatin/EHEC Factor for Adherence-1 in the Pathogenesis of Gram Negative Infection. Toxins 2010, 2, 954-962.

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