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Toxins 2010, 2(5), 954-962; doi:10.3390/toxins2050954
Review

The Role of Lymphostatin/EHEC Factor for Adherence-1 in the Pathogenesis of Gram Negative Infection

Division of Digestive Diseases, Emory University, Atlanta GA 30322, USA
Received: 21 March 2010 / Revised: 22 April 2010 / Accepted: 27 April 2010 / Published: 5 May 2010
(This article belongs to the Special Issue Enterotoxins)
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Abstract

Lymphostatin/EHEC factor for adherence-1 is a novel large toxin represented in various Gram negative bacteria, highly associated with the development of infectious diarrhea and hemolytic uremic syndrome. In vitro and in vivo experiments identified lymphostatin/EFA-1 as a toxin with a central role in the pathogenesis of Gram negative bacteria, responsible for bacterial adhesion, intestinal colonization, immunosuppression, and disruption of gut epithelial barrier function.
Keywords: lymphocyte inhibitory factor A/EHEC factor for adherence-1; lymphostatin; Gram negative bacterial toxin; Enteropathogenic E. coli; Enterohemorrhagic E. coli; immunosuppression; Citrobacter rodentium; intestinal epithelial barrier function lymphocyte inhibitory factor A/EHEC factor for adherence-1; lymphostatin; Gram negative bacterial toxin; Enteropathogenic E. coli; Enterohemorrhagic E. coli; immunosuppression; Citrobacter rodentium; intestinal epithelial barrier function
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Klapproth, J.-M. The Role of Lymphostatin/EHEC Factor for Adherence-1 in the Pathogenesis of Gram Negative Infection. Toxins 2010, 2, 954-962.

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