Special Issue "Neuroprotective Strategies"

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A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Medicinal Chemistry".

Deadline for manuscript submissions: closed (15 August 2010)

Special Issue Editor

Guest Editor
Dr. Katalin Prokai-Tatrai
Department of Pharmacology & Neuroscience, University of North Texas Health Science Center, 3500 Camp Bowie Blvd, Fort Worth, TX 76107, USA
Website: https://profile.hsc.unt.edu/profilesystem/viewprofile.php?pid=101052
E-Mail: katalin.prokai@unthsc.edu
Phone: +1 871 735 0617
Fax: +1 817 735 2118
Interests: medicinal chemistry: drug design of central nervous system agents; neuropeptides and peptidomimetics; prodrugs for CNS delivery; oxidative stress; estrogens and other phenolic antioxidants; protein carbonylation

Special Issue Information

Dear Colleagues,

This special issue is aimed at both the basic science and clinical aspects of neuroprotective approaches to acute (e.g., brain or spinal cord trauma, stroke), and chronic neurodegenerative (e.g., Alzheimer's and Parkinson's diseases, age-related macular degeneration) diseases. Potential and existing interventions, either as reviews or original papers, to prevent neuronal cell death in the CNS and in the periphery are welcome to this special issue. The concept of neuroprotection in therapeutic terms may be best described by Shouldon (Science, 1998; 282:1072) as "pharmacological interventions that produce enduring benefits by favorably influencing underlying etiology or pathogenesis and thereby forestalling onset of disease or clinical decline." Our life span has increased and it brought about a significant increase in the incidence of neurodegenerative diseases. While each neurodegenerative disease has its own characteristics and clinical manifestations, some common markers have been recognized. Among others, increased levels of oxidative/nitrosative damage to DNA, RNA, mitochondria, membranes, and proteins, etc. have been detected in connection with situations of neuronal damage. The wide variety of approaches to rescue neurons includes free radical scavenging antioxidants, ion channel modulators, excitatory amino acid antagonists and neurotrophic factors. Stem-cell based approaches may also represent a new opportunity to treat neurodegenerative diseases. I wish to thank all the authors for their contribution to this special issue.

Dr. Katalin Prokai-Tatrai
Guest Editor

Keywords

  • aging
  • Alzheimer's disease
  • amyotrophic lateral sclerosis
  • anti-apoptotic drugs
  • antioxidants
  • apoptosis
  • axon damage
  • bioavailability
  • blood-brain barrier
  • caspases
  • cognition
  • excitotoxicity
  • free radicals
  • GABA agonists
  • glaucoma
  • growth factors
  • hydroxyl radical
  • hypothermia
  • hypoxia
  • inflammation
  • ion channels
  • iron chelators
  • ischemia
  • ischemic optic neuropathy
  • lipid peroxidation
  • MEK/ERK signaling pathway
  • mitochondria
  • necrosis
  • neurogenesis
  • neurotrophic factors
  • nitric oxide synthase
  • nitrosative/oxidative stress
  • NMDA agonist
  • nutraceuticals
  • Parkinson’s disease
  • peripheral neurons
  • peroxinitrite
  • posttranslational modification
  • protein aggregates
  • proteomics
  • redox-active metals
  • retinal ganglion cells
  • spinal cord injury
  • stem cell
  • steroids
  • stroke
  • superoxide dismutase
  • therapeutic window
  • traumatic brain injury

Related Special Issue

Published Papers (17 papers)

by  and
Molecules 2010, 15(12), 9104-9134; doi:10.3390/molecules15129104
Received: 29 October 2010; in revised form: 29 November 2010 / Accepted: 8 December 2010 / Published: 10 December 2010
Show/Hide Abstract | Cited by 4 | PDF Full-text (207 KB)

by ,  and
Molecules 2010, 15(11), 7792-7814; doi:10.3390/molecules15117792
Received: 15 October 2010; Accepted: 20 October 2010 / Published: 3 November 2010
Show/Hide Abstract | Cited by 72 | PDF Full-text (1781 KB)

by ,  and
Molecules 2010, 15(10), 6859-6887; doi:10.3390/molecules15106859
Received: 19 August 2010; in revised form: 6 September 2010 / Accepted: 8 September 2010 / Published: 8 October 2010
Show/Hide Abstract | Cited by 15 | PDF Full-text (2865 KB)

by , , , ,  and
Molecules 2010, 15(10), 6678-6687; doi:10.3390/molecules15106678
Received: 11 August 2010; in revised form: 16 September 2010 / Accepted: 19 September 2010 / Published: 28 September 2010
Show/Hide Abstract | Cited by 2 | PDF Full-text (444 KB)
abstract graphic

by , ,  and
Molecules 2010, 15(9), 6598-6618; doi:10.3390/molecules15096598
Received: 16 August 2010; in revised form: 10 September 2010 / Accepted: 14 September 2010 / Published: 20 September 2010
Show/Hide Abstract | Cited by 10 | PDF Full-text (198 KB)

by ,  and
Molecules 2010, 15(9), 6050-6105; doi:10.3390/molecules15096050
Received: 18 June 2010; in revised form: 24 August 2010 / Accepted: 30 August 2010 / Published: 31 August 2010
Show/Hide Abstract | Cited by 12 | PDF Full-text (1229 KB)

by , ,  and
Molecules 2010, 15(8), 5246-5257; doi:10.3390/molecules15085246
Received: 14 July 2010; in revised form: 28 July 2010 / Accepted: 30 July 2010 / Published: 2 August 2010
Show/Hide Abstract | Cited by 7 | PDF Full-text (237 KB)
abstract graphic

by  and
Molecules 2010, 15(7), 4984-5011; doi:10.3390/molecules15074984
Received: 30 April 2010; in revised form: 15 July 2010 / Accepted: 19 July 2010 / Published: 20 July 2010
Show/Hide Abstract | Cited by 5 | PDF Full-text (616 KB)

by , ,  and
Molecules 2010, 15(5), 3517-3555; doi:10.3390/molecules15053517
Received: 21 February 2010; in revised form: 31 March 2010 / Accepted: 6 May 2010 / Published: 14 May 2010
Show/Hide Abstract | Cited by 13 | PDF Full-text (5057 KB)

by ,  and
Molecules 2010, 15(5), 3038-3047; doi:10.3390/molecules15053038
Received: 22 February 2010; in revised form: 13 April 2010 / Accepted: 26 April 2010 / Published: 27 April 2010
Show/Hide Abstract | Cited by 4 | PDF Full-text (595 KB)

by , , , ,  and
Molecules 2010, 15(3), 1168-1195; doi:10.3390/molecules15031168
Received: 31 December 2009; in revised form: 5 February 2010 / Accepted: 2 March 2010 / Published: 3 March 2010
Show/Hide Abstract | Cited by 4 | PDF Full-text (227 KB)

by  and
Molecules 2010, 15(3), 1196-1212; doi:10.3390/molecules15031196
Received: 31 December 2009; in revised form: 17 February 2010 / Accepted: 2 March 2010 / Published: 3 March 2010
Show/Hide Abstract | Cited by 13 | PDF Full-text (367 KB)

by , ,  and
Molecules 2010, 15(2), 878-916; doi:10.3390/molecules15020878
Received: 9 December 2009; in revised form: 12 January 2010 / Accepted: 1 February 2010 / Published: 10 February 2010
Show/Hide Abstract | Cited by 26 | PDF Full-text (361 KB)

by , , , ,  and
Molecules 2010, 15(1), 114-127; doi:10.3390/molecules15010114
Received: 5 November 2009; in revised form: 18 December 2009 / Accepted: 28 December 2009 / Published: 30 December 2009
Show/Hide Abstract | Cited by 6 | PDF Full-text (1340 KB)

by , , , , , ,  and
Molecules 2009, 14(12), 5115-5123; doi:10.3390/molecules14125115
Received: 20 October 2009; in revised form: 26 November 2009 / Accepted: 4 December 2009 / Published: 9 December 2009
Show/Hide Abstract | Cited by 7 | PDF Full-text (432 KB)

by
Molecules 2009, 14(12), 5054-5102; doi:10.3390/molecules14125054
Received: 12 November 2009; in revised form: 30 November 2009 / Accepted: 4 December 2009 / Published: 7 December 2009
Show/Hide Abstract | Cited by 16 | PDF Full-text (283 KB)

by , , ,  and
Molecules 2009, 14(9), 3392-3410; doi:10.3390/molecules14093392
Received: 27 July 2009; in revised form: 14 August 2009 / Accepted: 1 September 2009 / Published: 3 September 2009
Show/Hide Abstract | Cited by 1 | PDF Full-text (278 KB)
abstract graphic

Last update: 8 August 2014

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