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Dealing with Misfolded Proteins: Examining the Neuroprotective Role of Molecular Chaperones in Neurodegeneration
Department of Molecular and Cellular Pharmacology, University of Miami, Miller School of Medicine, Miami, FL 33136, USA
Neuroscience Graduate Program, University of Miami, Miller School of Medicine, Miami, FL 33136, USA
These two authors contributed equally to this work.
* Author to whom correspondence should be addressed.
Received: 19 August 2010; in revised form: 6 September 2010 / Accepted: 8 September 2010 / Published: 8 October 2010
Abstract: Human neurodegenerative diseases arise from a wide array of genetic and environmental factors. Despite the diversity in etiology, many of these diseases are considered "conformational" in nature, characterized by the accumulation of pathological, misfolded proteins. These misfolded proteins can induce cellular stress by overloading the proteolytic machinery, ultimately resulting in the accumulation and deposition of aggregated protein species that are cytotoxic. Misfolded proteins may also form aberrant, non-physiological protein-protein interactions leading to the sequestration of other normal proteins essential for cellular functions. The progression of such disease may therefore be viewed as a failure of normal protein homeostasis, a process that involves a network of molecules regulating the synthesis, folding, translocation and clearance of proteins. Molecular chaperones are highly conserved proteins involved in the folding of nascent proteins, and the repair of proteins that have lost their typical conformations. These functions have therefore made molecular chaperones an active area of investigation within the field of conformational diseases. This review will discuss the role of molecular chaperones in neurodegenerative diseases, highlighting their functional classification, regulation, and therapeutic potential for such diseases.
Keywords: Alzheimer’s disease; Parkinson’s disease; PolyQ disease; Hsp90; Hsp70
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Ali, Y.O.; Kitay, B.M.; Zhai, R.G. Dealing with Misfolded Proteins: Examining the Neuroprotective Role of Molecular Chaperones in Neurodegeneration. Molecules 2010, 15, 6859-6887.
Ali YO, Kitay BM, Zhai RG. Dealing with Misfolded Proteins: Examining the Neuroprotective Role of Molecular Chaperones in Neurodegeneration. Molecules. 2010; 15(10):6859-6887.
Ali, Yousuf O.; Kitay, Brandon M.; Zhai, R. Grace. 2010. "Dealing with Misfolded Proteins: Examining the Neuroprotective Role of Molecular Chaperones in Neurodegeneration." Molecules 15, no. 10: 6859-6887.