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trans-Resveratrol as A Neuroprotectant
Department of Biological Sciences, Brock University, St. Catharines, ON, L2S 3A1, Canada
* Author to whom correspondence should be addressed.
Received: 31 December 2009; in revised form: 17 February 2010 / Accepted: 2 March 2010 / Published: 3 March 2010
Abstract: Epidemiological evidence indicates that nutritionally-derived polyphenols such as resveratrol (RES) have neuroprotective properties. Administration of RES to culture media protects a wide variety of neuronal cell types from stress-induced death. Dietary supplementation of RES can ameliorate neuronal damage and death resulting from both acute and chronic stresses in rodents. The specific molecular mechanisms by which RES acts at the cellular level remain incompletely understood. However, many experimental data indicate that RES reduces or prevents the occurrence of oxidative damage. Here we discuss possible mechanisms by which RES might exert protection against oxidative damage and cell death. Evidence suggesting that RES’s chemical antioxidant potential is not sufficient explanation for its effects is discussed. Putative biological activities, including interactions with estrogen receptors and sirtuins are critically discussed. We provide a synthesis of how RES’s phytoestrogenic properties might mediate the neuronal stress resistance underlying its observed neuroprotective properties.
Keywords: resveratrol; mitochondria; MnSOD; superoxide dismutase; reactive oxygen species; ROS; estrogen; phytoestrogen; stress resistance; neuroprotection
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MDPI and ACS Style
Robb, E.L.; Stuart, J.A. trans-Resveratrol as A Neuroprotectant. Molecules 2010, 15, 1196-1212.
Robb EL, Stuart JA. trans-Resveratrol as A Neuroprotectant. Molecules. 2010; 15(3):1196-1212.
Robb, Ellen L.; Stuart, Jeffrey A. 2010. "trans-Resveratrol as A Neuroprotectant." Molecules 15, no. 3: 1196-1212.