Molecules 2010, 15(12), 9104-9134; doi:10.3390/molecules15129104
Review

Experimental Models for Assaying Microvascular Endothelial Cell Pathophysiology in Stroke

Department of Neurology, Girona Biomedical Research Institute (IdIBGi), Dr. Josep Trueta University Hospital, Av de França s/n, 17007 Girona, Spain
* Author to whom correspondence should be addressed.
Received: 29 October 2010; in revised form: 29 November 2010 / Accepted: 8 December 2010 / Published: 10 December 2010
(This article belongs to the Special Issue Neuroprotective Strategies)
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Abstract: It is important to understand the molecular mechanisms underlying neuron death following stroke in order to develop effective neuroprotective strategies. Since studies on human stroke are extremely limited due to the difficulty in collecting post-mortem tissue at different time points after the onset of stroke, brain ischaemia research focuses on information derived from in-vitro models of neuronal death through ischaemic injury [1]. This review aims to provide an update on the different in-vitro stroke models with brain microvascular endothelial cells that are currently being used. These models provide a physiologically relevant tool to screen potential neuroprotective drugs in stroke and to study the molecular mechanisms involved in brain ischaemia.
Keywords: neuroprotection; blood brain barrier; brain endothelial cells; cerebral ischaemia; angiogenesis

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MDPI and ACS Style

Camós, S.; Mallolas, J. Experimental Models for Assaying Microvascular Endothelial Cell Pathophysiology in Stroke. Molecules 2010, 15, 9104-9134.

AMA Style

Camós S, Mallolas J. Experimental Models for Assaying Microvascular Endothelial Cell Pathophysiology in Stroke. Molecules. 2010; 15(12):9104-9134.

Chicago/Turabian Style

Camós, Susanna; Mallolas, Judith. 2010. "Experimental Models for Assaying Microvascular Endothelial Cell Pathophysiology in Stroke." Molecules 15, no. 12: 9104-9134.

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