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Molecules 2010, 15(12), 9104-9134; doi:10.3390/molecules15129104
Review

Experimental Models for Assaying Microvascular Endothelial Cell Pathophysiology in Stroke

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Received: 29 October 2010 / Revised: 29 November 2010 / Accepted: 8 December 2010 / Published: 10 December 2010
(This article belongs to the Special Issue Neuroprotective Strategies)
Download PDF [207 KB, 18 June 2014; original version 18 June 2014]

Abstract

It is important to understand the molecular mechanisms underlying neuron death following stroke in order to develop effective neuroprotective strategies. Since studies on human stroke are extremely limited due to the difficulty in collecting post-mortem tissue at different time points after the onset of stroke, brain ischaemia research focuses on information derived from in-vitro models of neuronal death through ischaemic injury [1]. This review aims to provide an update on the different in-vitro stroke models with brain microvascular endothelial cells that are currently being used. These models provide a physiologically relevant tool to screen potential neuroprotective drugs in stroke and to study the molecular mechanisms involved in brain ischaemia.
Keywords: neuroprotection; blood brain barrier; brain endothelial cells; cerebral ischaemia; angiogenesis neuroprotection; blood brain barrier; brain endothelial cells; cerebral ischaemia; angiogenesis
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Camós, S.; Mallolas, J. Experimental Models for Assaying Microvascular Endothelial Cell Pathophysiology in Stroke. Molecules 2010, 15, 9104-9134.

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