Special Issue "Neuroprotective Strategies"

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A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology".

Deadline for manuscript submissions: closed (15 August 2010)

Special Issue Editor

Guest Editor
Dr. Katalin Prokai-Tatrai
Department of Pharmacology & Neuroscience, University of North Texas Health Science Center, 3500 Camp Bowie Blvd, Fort Worth, TX 76107, USA
Website: https://profile.hsc.unt.edu/profilesystem/viewprofile.php?pid=101052
E-Mail: katalin.prokai@unthsc.edu
Phone: +1 871 735 0617
Fax: +1 817 735 2118
Interests: medicinal chemistry: drug design of central nervous system agents; neuropeptides and peptidomimetics; prodrugs for CNS delivery; oxidative stress; estrogens and other phenolic antioxidants; protein carbonylation

Special Issue Information

Dear Colleagues,

This Special Issue is aimed at both the basic science and clinical aspects of neuroprotective approaches to acute (e.g., brain or spinal cord trauma, stroke), and chronic neurodegenerative (e.g., Alzheimer's and Parkinson's diseases, age-related macular degeneration) diseases. Potential and existing interventions, either as reviews or original papers, to prevent neuronal cell death in the CNS and in the periphery are welcome to this special issue. The concept of neuroprotection in therapeutic terms may be best described by Shouldon (Science, 1998; 282:1072) as "pharmacological interventions that produce enduring benefits by favorably influencing underlying etiology or pathogenesis and thereby forestalling onset of disease or clinical decline." Our life span has increased and it brought about a significant increase in the incidence of neurodegenerative diseases. While each neurodegenerative disease has its own characteristics and clinical manifestations, some common markers have been recognized. Among others, increased levels of oxidative/nitrosative damage to DNA, RNA, mitochondria, membranes, and proteins, etc. have been detected in connection with situations of neuronal damage. The wide variety of approaches to rescue neurons includes free radical scavenging antioxidants, ion channel modulators, excitatory amino acid antagonists and neurotrophic factors. Stem-cell based approaches may also represent a new opportunity to treat neurodegenerative diseases. I wish to thank all the authors for their contribution to this special issue.

Katalin Prokai-Tatrai, Ph. D.
Guest Editor

Related Special Issues in other Journals

Neuroprotective Strategies in Molecules

Keywords

aging, Alzheimer's disease, amyotrophic lateral sclerosis, anti-apoptotic drugs, antioxidants, apoptosis, axon damage, bioavailability, blood-brain barrier, caspases, cognition, excitotoxicity, free radicals, GABA agonists, glaucoma, growth factors, hydroxyl radical, hypothermia, hypoxia, inflammation, ion channels, iron chelators, ischemia, ischemic optic neuropathy, lipid peroxidation, MEK/ERK signaling pathway, mitochondria, necrosis, neurogenesis, neurotrophic factors, nitric oxide synthase, nitrosative/oxidative stress, NMDA agonist, nutraceuticals, Parkinson’s disease, peripheral neurons, peroxinitrite, posttranslational modification, protein aggregates, proteomics, redox-active metals, retinal ganglion cells, spinal cord injury, stem cell, steroids, stroke, superoxide dismutase, therapeutic window, traumatic brain injury

Published Papers (18 papers)

Int. J. Mol. Sci. 2011, 12(3), 1533-1562; doi:10.3390/ijms12031533
Received: 17 August 2010; in revised form: 10 February 2011 / Accepted: 22 February 2011 / Published: 25 February 2011
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Int. J. Mol. Sci. 2011, 12(1), 694-724; doi:10.3390/ijms12010694
Received: 2 December 2010; in revised form: 14 January 2011 / Accepted: 15 January 2011 / Published: 19 January 2011
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Int. J. Mol. Sci. 2011, 12(1), 506-569; doi:10.3390/ijms12010506
Received: 18 November 2010; in revised form: 5 January 2011 / Accepted: 14 January 2011 / Published: 17 January 2011
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Int. J. Mol. Sci. 2010, 11(11), 4580-4590; doi:10.3390/ijms11114580
Received: 6 October 2010; in revised form: 30 October 2010 / Accepted: 30 October 2010 / Published: 16 November 2010
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Int. J. Mol. Sci. 2010, 11(11), 4465-4487; doi:10.3390/ijms11114465
Received: 20 September 2010; in revised form: 22 October 2010 / Accepted: 27 October 2010 / Published: 9 November 2010
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Int. J. Mol. Sci. 2010, 11(9), 3513-3528; doi:10.3390/ijms11093513
Received: 18 August 2010; in revised form: 15 September 2010 / Accepted: 15 September 2010 / Published: 21 September 2010
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Int. J. Mol. Sci. 2010, 11(8), 2875-2900; doi:10.3390/ijms11082875
Received: 24 May 2010; in revised form: 25 July 2010 / Accepted: 30 July 2010 / Published: 5 August 2010
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Int. J. Mol. Sci. 2010, 11(7), 2658-2669; doi:10.3390/ijms11072658
Received: 4 June 2010; in revised form: 2 July 2010 / Accepted: 2 July 2010 / Published: 7 July 2010
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Int. J. Mol. Sci. 2010, 11(6), 2306-2321; doi:10.3390/ijms11062306
Received: 10 May 2010; in revised form: 24 May 2010 / Accepted: 24 May 2010 / Published: 27 May 2010
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Int. J. Mol. Sci. 2010, 11(6), 2291-2305; doi:10.3390/ijms11062291
Received: 16 April 2010; Accepted: 21 May 2010 / Published: 26 May 2010
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Int. J. Mol. Sci. 2010, 11(5), 2109-2117; doi:10.3390/ijms11052109
Received: 28 March 2010; in revised form: 13 April 2010 / Accepted: 3 May 2010 / Published: 11 May 2010
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Int. J. Mol. Sci. 2010, 11(5), 2039-2055; doi:10.3390/ijms11052039
Received: 23 March 2010; in revised form: 8 April 2010 / Accepted: 18 April 2010 / Published: 5 May 2010
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Int. J. Mol. Sci. 2010, 11(4), 1253-1268; doi:10.3390/ijms11041253
Received: 3 November 2009; in revised form: 11 March 2010 / Accepted: 22 March 2010 / Published: 26 March 2010
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Int. J. Mol. Sci. 2010, 11(2), 544-561; doi:10.3390/ijms11020544
Received: 7 January 2010; in revised form: 27 January 2010 / Accepted: 27 January 2010 / Published: 3 February 2010
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Int. J. Mol. Sci. 2010, 11(1), 312-328; doi:10.3390/ijms11010312
Received: 23 December 2009; Accepted: 15 January 2010 / Published: 21 January 2010
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Int. J. Mol. Sci. 2010, 11(1), 140-153; doi:10.3390/ijms11010140
Received: 13 November 2009; in revised form: 4 January 2010 / Accepted: 7 January 2010 / Published: 12 January 2010
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Int. J. Mol. Sci. 2010, 11(1), 107-123; doi:10.3390/ijms11010107
Received: 4 November 2009; in revised form: 31 December 2009 / Accepted: 1 January 2010 / Published: 8 January 2010
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Int. J. Mol. Sci. 2009, 10(11), 4789-4804; doi:10.3390/ijms10114789
Received: 17 September 2009; in revised form: 21 October 2009 / Accepted: 2 November 2009 / Published: 5 November 2009
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Last update: 26 February 2014

Int. J. Mol. Sci. EISSN 1422-0067 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert