Special Issue "Neuroprotective Strategies 2012"

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A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology".

Deadline for manuscript submissions: closed (31 July 2012)

Special Issue Editor

Guest Editor
Dr. Katalin Prokai-Tatrai
Department of Pharmacology & Neuroscience, University of North Texas Health Science Center, 3500 Camp Bowie Blvd, Fort Worth, TX 76107, USA
Website: https://profile.hsc.unt.edu/profilesystem/viewprofile.php?pid=101052
E-Mail: katalin.prokai@unthsc.edu
Phone: +1 871 735 0617
Fax: +1 817 735 2118
Interests: medicinal chemistry: drug design of central nervous system agents; neuropeptides and peptidomimetics; prodrugs for CNS delivery; oxidative stress; estrogens and other phenolic antioxidants; protein carbonylation

Special Issue Information

Dear Colleagues,

This special issue is aimed at both the basic science and clinical aspects of neuroprotective approaches to acute (e.g., brain or spinal cord trauma, stroke), and chronic neurodegenerative (e.g., Alzheimer's and Parkinson's diseases, age-related macular degeneration) diseases. Potential and existing interventions, either as reviews or original papers, to prevent neuronal cell death in the CNS and in the periphery are welcome to this special issue. The concept of neuroprotection in therapeutic terms may be best described by Shouldon (Science, 1998; 282:1072) as "pharmacological interventions that produce enduring benefits by favorably influencing underlying etiology or pathogenesis and thereby forestalling onset of disease or clinical decline." Our life span has increased and it brought about a significant increase in the incidence of neurodegenerative diseases. While each neurodegenerative disease has its own characteristics and clinical manifestations, some common markers have been recognized. Among others, increased levels of oxidative/nitrosative damage to DNA, RNA, mitochondria, membranes, and proteins, etc. have been detected in connection with situations of neuronal damage. The wide variety of approaches to rescue neurons includes free radical scavenging antioxidants, ion channel modulators, excitatory amino acid antagonists and neurotrophic factors. Stem-cell based approaches may also represent a new opportunity to treat neurodegenerative diseases. I wish to thank all the authors for their contribution to this special issue.

Dr. Katalin Prokai-Tatrai
Guest Editor

Keywords

  • aging
  • Alzheimer's disease
  • amyotrophic lateral sclerosis
  • anti-apoptotic drugs; antioxidants
  • apoptosis
  • axon damage
  • bioavailability
  • blood-brain barrier
  • caspases; cognition
  • excitotoxicity
  • free radicals
  • GABA agonists
  • glaucoma
  • growth factors
  • hydroxyl radical
  • hypothermia
  • hypoxia
  • inflammation; ion channels
  • ron chelators; ischemia
  • ischemic optic neuropathy
  • lipid peroxidation
  • MEK/ERK signaling pathway
  • mitochondria; necrosis
  • neurogenesis
  • neurotrophic factors
  • nitric oxide synthase
  • nitrosative/oxidative stress
  • NMDA agonist
  • nutraceuticals
  • Parkinson’s disease
  • peripheral neurons
  • peroxinitrite
  • posttranslational modification
  • protein aggregates
  • proteomics
  • redox-active metals
  • retinal ganglion cells
  • spinal cord injury
  • stem cell; steroids
  • stroke
  • superoxide dismutase
  • therapeutic window
  • traumatic brain injury

Published Papers (18 papers)

Int. J. Mol. Sci. 2013, 14(2), 2559-2572; doi:10.3390/ijms14022559
Received: 29 September 2012; in revised form: 12 January 2013 / Accepted: 17 January 2013 / Published: 28 January 2013
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Int. J. Mol. Sci. 2013, 14(1), 1443-1454; doi:10.3390/ijms14011443
Received: 13 December 2012; in revised form: 3 January 2013 / Accepted: 5 January 2013 / Published: 11 January 2013
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Int. J. Mol. Sci. 2012, 13(10), 12939-12951; doi:10.3390/ijms131012939
Received: 19 July 2012; in revised form: 28 August 2012 / Accepted: 21 September 2012 / Published: 10 October 2012
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Int. J. Mol. Sci. 2012, 13(10), 12911-12924; doi:10.3390/ijms131012911
Received: 2 August 2012; in revised form: 7 September 2012 / Accepted: 7 September 2012 / Published: 10 October 2012
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Int. J. Mol. Sci. 2012, 13(10), 12629-12655; doi:10.3390/ijms131012629
Received: 1 August 2012; in revised form: 19 September 2012 / Accepted: 24 September 2012 / Published: 3 October 2012
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Int. J. Mol. Sci. 2012, 13(9), 11783-11803; doi:10.3390/ijms130911783
Received: 7 August 2012; in revised form: 5 September 2012 / Accepted: 7 September 2012 / Published: 18 September 2012
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Int. J. Mol. Sci. 2012, 13(9), 11753-11772; doi:10.3390/ijms130911753
Received: 29 July 2012; in revised form: 6 September 2012 / Accepted: 7 September 2012 / Published: 18 September 2012
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Int. J. Mol. Sci. 2012, 13(9), 11584-11592; doi:10.3390/ijms130911584
Received: 1 August 2012; in revised form: 10 September 2012 / Accepted: 11 September 2012 / Published: 14 September 2012
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Int. J. Mol. Sci. 2012, 13(9), 11543-11568; doi:10.3390/ijms130911543
Received: 9 July 2012; in revised form: 23 August 2012 / Accepted: 4 September 2012 / Published: 14 September 2012
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Int. J. Mol. Sci. 2012, 13(9), 11102-11129; doi:10.3390/ijms130911102
Received: 11 July 2012; in revised form: 16 August 2012 / Accepted: 30 August 2012 / Published: 6 September 2012
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Int. J. Mol. Sci. 2012, 13(9), 10899-10910; doi:10.3390/ijms130910899
Received: 1 August 2012; in revised form: 20 August 2012 / Accepted: 22 August 2012 / Published: 30 August 2012
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Int. J. Mol. Sci. 2012, 13(8), 10608-10629; doi:10.3390/ijms130810608
Received: 26 July 2012; in revised form: 13 August 2012 / Accepted: 14 August 2012 / Published: 23 August 2012
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Int. J. Mol. Sci. 2012, 13(7), 8670-8678; doi:10.3390/ijms13078670
Received: 7 May 2012; in revised form: 21 June 2012 / Accepted: 3 July 2012 / Published: 12 July 2012
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Int. J. Mol. Sci. 2012, 13(7), 8430-8448; doi:10.3390/ijms13078430
Received: 11 May 2012; in revised form: 25 June 2012 / Accepted: 26 June 2012 / Published: 6 July 2012
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Int. J. Mol. Sci. 2012, 13(6), 7739-7761; doi:10.3390/ijms13067739
Received: 15 May 2012; in revised form: 15 June 2012 / Accepted: 19 June 2012 / Published: 21 June 2012
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Int. J. Mol. Sci. 2012, 13(6), 7424-7444; doi:10.3390/ijms13067424
Received: 9 March 2012; in revised form: 4 June 2012 / Accepted: 5 June 2012 / Published: 15 June 2012
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Int. J. Mol. Sci. 2012, 13(6), 6995-7014; doi:10.3390/ijms13066995
Received: 28 April 2012; in revised form: 25 May 2012 / Accepted: 31 May 2012 / Published: 7 June 2012
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Int. J. Mol. Sci. 2012, 13(5), 6303-6319; doi:10.3390/ijms13056303
Received: 9 April 2012; in revised form: 8 May 2012 / Accepted: 14 May 2012 / Published: 22 May 2012
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Last update: 26 February 2014

Int. J. Mol. Sci. EISSN 1422-0067 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert