Special Issue "Neurological Injuries’ Monitoring, Tracking and Treatment"

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A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Biochemistry, Molecular Biology and Biophysics".

Deadline for manuscript submissions: 25 March 2015

Special Issue Editor

Guest Editor
Prof. Dr. Xiaofeng Jia
Department of Neurosurgery, University of Maryland School of Medicine; Department of Biomedical Engineering; Physical Medicine and Rehabilitation; Anesthesiology and Critical Care Medicine, Johns Hopkins University School of Medicine 10 South Pine Street, MSTF RM 5-59, Baltimore, MD 21201
Website: http://medschool.umaryland.edu/xjia/
E-Mail: xjia@smail.umaryland.edu
Phone: +410 706 5025
Interests: brain monitoring and therapeutic hypothermia; peripheral nerve injury and regeneration; translational therapeutic model for neurological injuries; development and characterization of biomaterials for bone and peripheral nerve regeneration

Special Issue Information

Dear Colleagues,

Despite recent advancements, the monitoring and tracking of neurological injuries are still major hindrances in the development of neurological injury therapies. Current monitoring methodologies have been largely limited to post-injury evaluation and prognostication. Induced hypothermia improves both survival and neurological outcome in cardiac arrest survivors. However, the monitoring methodologies to guide hypothermia therapy and improve its efficiency are not currently satisfying. Among the most exciting research areas, stem cell biology recently burst out and holds significant promise in the repair of neurological injuries. However, the role and effect of stem cell therapy still remain un-elucidated.

The goal of this Special Issue is to provide a summary of the field, describe its impact as well as introduce the recent advances in the Neurological Injuries' Monitoring, Tracking and Treatment. We invite authors to submit original research and review articles related with neurological injury; mainly brain injury after cardiac arrest, stroke and traumatic brain injury, but spinal cord injury as well. We are interested in articles that explore the advances in neuroengineering and latest technologies in monitoring and tracking neurological injury from translational model to clinical evaluation, such as electrophysiological monitoring and the optogenesis technique. This issue will address novel therapeutic intervention in humans and also in animal models, including therapeutic hypothermia and stem cell therapy.

Dr. Xiaofeng Jia
Guest Editor

Submission

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. Papers will be published continuously (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are refereed through a peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed Open Access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1600 CHF (Swiss Francs).

Keywords

  • brain injury
  • cardiac arrest
  • stroke
  • traumatic brain injury
  • spinal cord injury
  • brain monitoring
  • electrophysiology
  • therapeutic hypothermia
  • stem cell
  • optogenesis
  • translational model
  • functional outcome
  • neuroengineering
  • clinical evaluation

Published Papers (11 papers)

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Displaying article 1-11
p. 22492-22517
by , , ,  and
Int. J. Mol. Sci. 2014, 15(12), 22492-22517; doi:10.3390/ijms151222492
Received: 3 October 2014; in revised form: 17 November 2014 / Accepted: 20 November 2014 / Published: 5 December 2014
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(This article belongs to the Special Issue Neurological Injuries’ Monitoring, Tracking and Treatment)
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p. 17014-17034
by , , , , ,  and
Int. J. Mol. Sci. 2014, 15(9), 17014-17034; doi:10.3390/ijms150917014
Received: 27 June 2014; in revised form: 5 September 2014 / Accepted: 10 September 2014 / Published: 23 September 2014
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(This article belongs to the Special Issue Neurological Injuries’ Monitoring, Tracking and Treatment)
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p. 12651-12664
by , , , , ,  and
Int. J. Mol. Sci. 2014, 15(7), 12651-12664; doi:10.3390/ijms150712651
Received: 30 April 2014; in revised form: 3 July 2014 / Accepted: 4 July 2014 / Published: 17 July 2014
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(This article belongs to the Special Issue Neurological Injuries’ Monitoring, Tracking and Treatment)
p. 12061-12073
by , , , ,  and
Int. J. Mol. Sci. 2014, 15(7), 12061-12073; doi:10.3390/ijms150712061
Received: 31 March 2014; in revised form: 23 June 2014 / Accepted: 25 June 2014 / Published: 7 July 2014
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(This article belongs to the Special Issue Neurological Injuries’ Monitoring, Tracking and Treatment)
p. 11275-11293
by , , , , , , , ,  and
Int. J. Mol. Sci. 2014, 15(7), 11275-11293; doi:10.3390/ijms150711275
Received: 15 May 2014; in revised form: 11 June 2014 / Accepted: 16 June 2014 / Published: 25 June 2014
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(This article belongs to the Special Issue Neurological Injuries’ Monitoring, Tracking and Treatment)
p. 9372-9385
by , , , ,  and
Int. J. Mol. Sci. 2014, 15(6), 9372-9385; doi:10.3390/ijms15069372
Received: 1 April 2014; in revised form: 29 April 2014 / Accepted: 12 May 2014 / Published: 27 May 2014
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(This article belongs to the Special Issue Neurological Injuries’ Monitoring, Tracking and Treatment)
p. 6504-6516
by , , , ,  and
Int. J. Mol. Sci. 2014, 15(4), 6504-6516; doi:10.3390/ijms15046504
Received: 20 February 2014; in revised form: 2 April 2014 / Accepted: 4 April 2014 / Published: 16 April 2014
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(This article belongs to the Special Issue Neurological Injuries’ Monitoring, Tracking and Treatment)
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p. 6378-6390
by , , , , ,  and
Int. J. Mol. Sci. 2014, 15(4), 6378-6390; doi:10.3390/ijms15046378
Received: 15 December 2013; in revised form: 25 March 2014 / Accepted: 31 March 2014 / Published: 15 April 2014
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(This article belongs to the Special Issue Neurological Injuries’ Monitoring, Tracking and Treatment)
p. 4431-4441
by , , , , , , , , ,  and
Int. J. Mol. Sci. 2014, 15(3), 4431-4441; doi:10.3390/ijms15034431
Received: 5 February 2014; in revised form: 27 February 2014 / Accepted: 28 February 2014 / Published: 13 March 2014
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(This article belongs to the Special Issue Neurological Injuries’ Monitoring, Tracking and Treatment)
p. 3088-3117
by , , , , ,  and
Int. J. Mol. Sci. 2014, 15(2), 3088-3117; doi:10.3390/ijms15023088
Received: 3 January 2014; in revised form: 3 February 2014 / Accepted: 10 February 2014 / Published: 20 February 2014
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(This article belongs to the Special Issue Neurological Injuries’ Monitoring, Tracking and Treatment)
p. 1418-1432
by , , , , , , , , , , , ,  and
Int. J. Mol. Sci. 2014, 15(1), 1418-1432; doi:10.3390/ijms15011418
Received: 13 November 2013; in revised form: 20 December 2013 / Accepted: 7 January 2014 / Published: 20 January 2014
Show/Hide Abstract | Cited by 3 | PDF Full-text (1504 KB) | HTML Full-text | XML Full-text | Supplementary Files
(This article belongs to the Special Issue Neurological Injuries’ Monitoring, Tracking and Treatment)
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Planned Papers

The below list represents only planned manuscripts. Some of these manuscripts have not been received by the Editorial Office yet. Papers submitted to MDPI journals are subject to peer-review.

Title: Pathogenesis of brain edema and investigations for anti-edema drugs
Authors: Shotaro Michinaga and Yutaka Koyama
Abstract:
Brain edema is a potentially fatal pathological state occurred in the early phases of stroke and head trauma. In edematous brain,
excess accumulation of extracellular fluid results in elevation of intracranial pressure leading to impair nerve function. Despite the
seriousness of brain edema, only symptomatic treatments to remove edema fluid are currently available. So, novel medications to prevent
induction of brain edema formations have been required. Pathogenesis of brain edema is classified into vasogenic edema and cytotoxic edema.
Vasogenic edema is defined as that induced by disruption of blood-brain barrier (BBB) and extravasations of serum proteins, which is thought to be a major pathogenesis of brain edema. To investigate mechanisms underlying induction of vasogenic brain edema, cold injury or fluid
percussion injury on animal brains are often used as experimental models. Many factors, including VEGFs, MMPs, chemokines and NO, are
confirmed as inducers of disruption of BBB and brain edema in these model animals. So, inhibitors of these vascular permeability factors are
expected to show anti-edema actions on damaged brain. In this review, we discuss the involvement of vascular permeability factors for brain
edema formation and possibility of anti-edema drugs targeting for these factors.

Title: Magnetoencephalography (MEG) Monitoring Stroke Patients Requiring Early, Intensive and Prolonged Rehabilitation
Author: Stefano Masiero
Abstract: An accurate early diagnosis and prognosis of stroke patients is crucial in order to select those patients which require early, intensive and prolonged rehabilitation, because have greater chances of response. Actually clinical assessment and structural brain scans cannot reliably determine the outcome of the affected people because inter individual variability of connectivity and neuroplasticity mechanisms can influence the evolution of brain damage. How well the brain is connected can be measured using functional magnetic resonance imaging (fMRI) brain scans but also with Electroencephalography/Magnetoencephalography (EEG/MEG). MEG has been experimentally used to detect early modifications in neuroplasticity and connectivity in people with stroke but the methods are not sensitive enough to be used as a clinical diagnostic test.
This review will focus on clinical use of MEG in neurorehabilitation.
Magnetoencephalography (MEG) is a non-invasive neurophysiological technique used to study the cerebral cortex. Currently, MEG is mainly used clinically to localize epileptic foci and eloquent brain areas to avoid damage during neurosurgery. MEG might, however, also be of help in the monitoring of stroke recovery and rehabilitation (Forss et al, 2011; Rossini et al, 2007). Action observation modulates activation of the viewer's motor (Hari et al, 1998) and somatosensory (Avikainen et al., 2002) cortex, with stronger motor-cortex effects for live than video presentation (Järveläinen et al, 2001). Moreover, natural language processing is well accessible with MEG, and it is possible to discriminate between spoken sentences, and suggested speech segmentation in a 200 ms window, even at a syllable level (Luo and Poeppel, 2007). Language production, which is very difficult to study with EEG and fMRI, due to wide-spread artifacts, can be more easily studied with MEG because the resulting signal recording can be better manipulated. MEG can facilitate the exploration of online interaction and communication (Hari and Kujala, 2009).
Measures of functional activity acquired with MEG while hemiplegic patients are either imagining, observing and executing simple movements will have higher accuracy than fMRI activity measures in the selection of good responders to motor rehabilitation. Analysis will focus on Event Related Desinchronizations (ERDS) in the motor/somatosensory cortex. Similarly MEG imaging should give better predictive outcomes in patients with aphasia following speech therapy (either using a cognitive neuropsychological approach or an intensive ecological language treatment). In this case, analysis with focus on Event Related Fields (ERFS) associated with communicative interaction.
To conduct a MEG review in Neurorehabilitation field, is very important because it should generate new data and answer specific performance questions that remain unanswered by the current body of experimental research. In neuromotor and speech rehabilitation there exists few shared method for making decisions on patient treatment duration and intensity.

Title: Advances in Intracranial Pressure Monitoring and its Significance in Managing Traumatic Brain Injury
Authors: Usmah Kawoos, Richard M McCarron and Mikulas Chavko
Abstract: Intracranial pressure (ICP) measurements are fundamental for the evaluation and treatment of many neurological disorders such as subarachnoid hemorrhage, intracerebral hemorrhage, ischemic stroke, and meningitis/encephalitis. In the realm of clinical and non-clinical work, the techniques of ICP monitoring have evolved from being simplistic with certain limitations to slightly complex methods offering advantages over the former methods. Some of the limitations of earlier methods of ICP monitoring include invasive and short-term monitoring, risks of infection and dislodgement of catheter based systems, restricted mobility of the subject etc. Although invasive in nature, ventriculostomy is considered to be the most accurate method of ICP monitoring. Invasive monitoring techniques can be simple in nature; however they demand the availability of some resources like appropriate facilities, trained personnel, critical care support, etc. The invasiveness of ICP measurement limits the frequency with which ICP can be evaluated, hampering the clinical care of patients with ICP disorders. Thus, there has been substantial interest in developing noninvasive methods for the assessment of ICP. Numerous approaches such as tympanic membrane displacement (TMD), optic nerve sheath diameter, fundoscopy, transcranial Doppler, near-infra red spectroscopy (NIRS), have been applied to the problem, although none seems to represent a complete solution because of their accuracy.
ICP measurements are fundamental in the present protocols for intensive care of patients during the acute stage of severe traumatic brain injury (TBI). TBI results in activation of primary and secondary pathophysiological processes which have an effect on ICP. In severe cases of TBI, elevated ICP is associated with mortality or poor clinical outcome. The main goal of ICP monitoring in TBI is to allow early detection of secondary damage and initiate immediate therapeutic intervention. The long-term continuous ICP monitoring is even beneficial as the pattern of changes in ICP can be used as a guide for individualized treatment. ICP monitoring in conjunction with other neurological monitoring can help in understanding the pathophysiological processes of the damage.
This review article presents, a) an overview of the significance of ICP monitoring, b) different ICP monitoring methods such as various invasive and non-invasive techniques and advantages and disadvantages of the techniques, and c) the role of ICP monitoring in brain damage, especially in the management of TBI.
Keywords: Intracranial pressure, invasive methods, non-invasive methods, telemetry, traumatic brain injury.

Last update: 18 December 2014

Int. J. Mol. Sci. EISSN 1422-0067 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert