Int. J. Mol. Sci. 2014, 15(2), 3088-3117; doi:10.3390/ijms15023088
Review

Nanostructured Guidance for Peripheral Nerve Injuries: A Review with a Perspective in the Oral and Maxillofacial Area

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Received: 3 January 2014; in revised form: 3 February 2014 / Accepted: 10 February 2014 / Published: 20 February 2014
(This article belongs to the Special Issue Neurological Injuries’ Monitoring, Tracking and Treatment)
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: Injury to peripheral nerves can occur as a result of various surgical procedures, including oral and maxillofacial surgery. In the case of nerve transaction, the gold standard treatment is the end-to-end reconnection of the two nerve stumps. When it cannot be performed, the actual strategies consist of the positioning of a nerve graft between the two stumps. Guided nerve regeneration using nano-structured scaffolds is a promising strategy to promote axon regeneration. Biodegradable electrospun conduits composed of aligned nanofibers is a new class of devices used to improve neurite extension and axon outgrowth. Self assembled peptide nanofibrous scaffolds (SAPNSs) demonstrated promising results in animal models for central nervous system injuries, and, more recently, for peripheral nerve injury. Aims of this work are (1) to review electrospun and self-assembled nanofibrous scaffolds use in vitro and in vivo for peripheral nerve regeneration; and (2) its application in peripheral nerve injuries treatment. The review focused on nanofibrous scaffolds with a diameter of less than approximately 250 nm. The conjugation in a nano scale of a natural bioactive factor with a resorbable synthetic or natural material may represent the best compromise providing both biological and mechanical cues for guided nerve regeneration. Injured peripheral nerves, such as trigeminal and facial, may benefit from these treatments.
Keywords: nanofiber; scaffold; nerve regeneration; electrospinning; self-assembly; SAPNS
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MDPI and ACS Style

Sivolella, S.; Brunello, G.; Ferrarese, N.; Della Puppa, A.; D'Avella, D.; Bressan, E.; Zavan, B. Nanostructured Guidance for Peripheral Nerve Injuries: A Review with a Perspective in the Oral and Maxillofacial Area. Int. J. Mol. Sci. 2014, 15, 3088-3117.

AMA Style

Sivolella S, Brunello G, Ferrarese N, Della Puppa A, D'Avella D, Bressan E, Zavan B. Nanostructured Guidance for Peripheral Nerve Injuries: A Review with a Perspective in the Oral and Maxillofacial Area. International Journal of Molecular Sciences. 2014; 15(2):3088-3117.

Chicago/Turabian Style

Sivolella, Stefano; Brunello, Giulia; Ferrarese, Nadia; Della Puppa, Alessandro; D'Avella, Domenico; Bressan, Eriberto; Zavan, Barbara. 2014. "Nanostructured Guidance for Peripheral Nerve Injuries: A Review with a Perspective in the Oral and Maxillofacial Area." Int. J. Mol. Sci. 15, no. 2: 3088-3117.

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