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Open AccessCommunication
Int. J. Mol. Sci. 2015, 16(2), 3226-3236; doi:10.3390/ijms16023226

MRS of Brain Metabolite Levels Demonstrates the Ability of Scavenging of Excess Brain Glutamate to Protect against Nerve Agent Induced Seizures

1
Department of Neurobiology, Weizmann Institute of Science, Rehovot 76100, Israel
2
Department of Veterinary Resources, Weizmann Institute of Science, Rehovot 76100, Israel
3
Department of Biological Chemistry, Weizmann Institute of Science, Rehovot 76100, Israel
These authors contributed equally to this work.
*
Author to whom correspondence should be addressed.
Academic Editor: Xiaofeng Jia
Received: 17 November 2014 / Accepted: 29 January 2015 / Published: 2 February 2015
(This article belongs to the Special Issue Neurological Injuries’ Monitoring, Tracking and Treatment)
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Abstract

This study describes the use of in vivo magnetic resonance spectrocopy (MRS) to monitor brain glutamate and lactate levels in a paraoxon (PO) intoxication model. Our results show that the administration of recombinant glutamate-oxaloacetate transaminase (rGOT) in combination with oxaloacetate (OxAc) significantly reduces the brain-accumulated levels of glutamate. Previously we have shown that the treatment causes a rapid decrease of blood glutamate levels and creates a gradient between the brain and blood glutamate levels which leads to the efflux of excess brain glutamate into the blood stream thereby reducing its potential to cause neurological damage. The fact that this treatment significantly decreased the brain glutamate and lactate levels following PO intoxication suggests that it could become a new effective neuroprotective agent. View Full-Text
Keywords: brain glutamate scavengers; oxaloacetate; hGOT; MRS; lactate brain glutamate scavengers; oxaloacetate; hGOT; MRS; lactate
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Ruban, A.; Biton, I.E.; Markovich, A.; Mirelman, D. MRS of Brain Metabolite Levels Demonstrates the Ability of Scavenging of Excess Brain Glutamate to Protect against Nerve Agent Induced Seizures. Int. J. Mol. Sci. 2015, 16, 3226-3236.

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