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Int. J. Mol. Sci. 2014, 15(4), 6504-6516; doi:10.3390/ijms15046504
Article

The Reliability and Predictive Ability of a Biomarker of Oxidative DNA Damage on Functional Outcomes after Stroke Rehabilitation

1,2
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3,4
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1,2
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5
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1,2,*  and 6
1 Department of Occupational Therapy and Graduate Institute of Behavioral Sciences, College of Medicine, Chang Gung University, Taoyuan 333, Taiwan 2 Healthy Aging Research Center, Chang Gung University, Taoyuan 333, Taiwan 3 School of Occupational Therapy, College of Medicine, National Taiwan University, Taipei 100, Taiwan 4 Division of Occupational Therapy, Department of Physical Medicine and Rehabilitation, National Taiwan University Hospital, Taipei 100, Taiwan 5 Stroke Center and Department of Neurology, Chang Gung Memorial Hospital, Linkou Medical Center and College of Medicine, Chang Gung University, Taoyuan 333, Taiwan 6 Institute of Occupational Medicine and Industrial Hygiene, National Taiwan University, Taipei 100, Taiwan
* Author to whom correspondence should be addressed.
Received: 20 February 2014 / Revised: 2 April 2014 / Accepted: 4 April 2014 / Published: 16 April 2014
(This article belongs to the Special Issue Neurological Injuries’ Monitoring, Tracking and Treatment)
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Abstract

We evaluated the reliability of 8-hydroxy-2'-deoxyguanosine (8-OHdG), and determined its ability to predict functional outcomes in stroke survivors. The rehabilitation effect on 8-OHdG and functional outcomes were also assessed. Sixty-one stroke patients received a 4-week rehabilitation. Urinary 8-OHdG levels were determined by liquid chromatography–tandem mass spectrometry. The test-retest reliability of 8-OHdG was good (interclass correlation coefficient = 0.76). Upper-limb motor function and muscle power determined by the Fugl-Meyer Assessment (FMA) and Medical Research Council (MRC) scales before rehabilitation showed significant negative correlation with 8-OHdG (r = −0.38, r = −0.30; p < 0.05). After rehabilitation, we found a fair and significant correlation between 8-OHdG and FMA (r = −0.34) and 8-OHdG and pain (r = 0.26, p < 0.05). Baseline 8-OHdG was significantly correlated with post-treatment FMA, MRC, and pain scores (r = −0.34, −0.31, and 0.25; p < 0.05), indicating its ability to predict functional outcomes. 8-OHdG levels were significantly decreased, and functional outcomes were improved after rehabilitation. The exploratory study findings conclude that 8-OHdG is a reliable and promising biomarker of oxidative stress and could be a valid predictor of functional outcomes in patients. Monitoring of behavioral indicators along with biomarkers may have crucial benefits in translational stroke research.
Keywords: oxidative stress; stroke; rehabilitation; biomarker; 8-OHdG; clinical evaluation oxidative stress; stroke; rehabilitation; biomarker; 8-OHdG; clinical evaluation
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).
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Hsieh, Y.-W.; Lin, K.-C.; Korivi, M.; Lee, T.-H.; Wu, C.-Y.; Wu, K.-Y. The Reliability and Predictive Ability of a Biomarker of Oxidative DNA Damage on Functional Outcomes after Stroke Rehabilitation. Int. J. Mol. Sci. 2014, 15, 6504-6516.

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