Posttraumatic Inflammation as a Key to Neuroregeneration after Traumatic Spinal Cord Injury
AbstractPro- and anti-inflammatory cytokines might have a large impact on the secondary phase and on the neurological outcome of patients with acute spinal cord injury (SCI). We measured the serum levels of different cytokines (Interferon-γ, Tumor Necrosis Factor-α, Interleukin-1β, IL-6, IL-8, IL-10, and Vascular Endothelial Growth Factor) over a 12-week period in 40 acute traumatic SCI patients: at admission on average one hour after initial trauma; at four, nine, 12, and 24 h; Three, and seven days after admission; and two, four, eight, and twelve weeks after admission. This was done using a Luminex Performance Human High Sensitivity Cytokine Panel. SCI was classified using the American Spinal Injury Association (ASIA) Impairment Scale (AIS) at time of admission and after 12 weeks. TNFα, IL-1β, IL-6, IL-8, and IL-10 concentrations were significantly higher in patients without neurological remission and in patients with an initial AIS A (p < 0.05). This study shows significant differences in cytokine concentrations shown in traumatic SCI patients with different neurological impairments and within a 12-week period. IL-8 and IL-10 are potential peripheral markers for neurological remission and rehabilitation after traumatic SCI. Furthermore our cytokine expression pattern of the acute, subacute, and intermediate phase of SCI establishes a possible basis for future studies to develop standardized monitoring, prognostic, and tracking techniques. View Full-Text
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Moghaddam, A.; Child, C.; Bruckner, T.; Gerner, H.J.; Daniel, V.; Biglari, B. Posttraumatic Inflammation as a Key to Neuroregeneration after Traumatic Spinal Cord Injury. Int. J. Mol. Sci. 2015, 16, 7900-7916.
Moghaddam A, Child C, Bruckner T, Gerner HJ, Daniel V, Biglari B. Posttraumatic Inflammation as a Key to Neuroregeneration after Traumatic Spinal Cord Injury. International Journal of Molecular Sciences. 2015; 16(4):7900-7916.Chicago/Turabian Style
Moghaddam, Arash; Child, Christopher; Bruckner, Thomas; Gerner, Hans J.; Daniel, Volker; Biglari, Bahram. 2015. "Posttraumatic Inflammation as a Key to Neuroregeneration after Traumatic Spinal Cord Injury." Int. J. Mol. Sci. 16, no. 4: 7900-7916.