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Keywords = yonarasterol

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11 pages, 311 KiB  
Article
Bioactive Compounds from a Gorgonian Coral Echinomuricea sp. (Plexauridae)
by Hsu-Ming Chung, Pei-Han Hong, Jui-Hsin Su, Tsong-Long Hwang, Mei-Chin Lu, Lee-Shing Fang, Yang-Chang Wu, Jan-Jung Li, Jih-Jung Chen, Wei-Hsien Wang and Ping-Jyun Sung
Mar. Drugs 2012, 10(5), 1169-1179; https://doi.org/10.3390/md10051169 - 23 May 2012
Cited by 19 | Viewed by 8385
Abstract
A new labdane-type diterpenoid, echinolabdane A (1), and a new sterol, 6-epi-yonarasterol B (2), were isolated from a gorgonian coral identified as Echinomuricea sp. The structures of metabolites 1 and 2 were elucidated by spectroscopic methods. Echinolabdane [...] Read more.
A new labdane-type diterpenoid, echinolabdane A (1), and a new sterol, 6-epi-yonarasterol B (2), were isolated from a gorgonian coral identified as Echinomuricea sp. The structures of metabolites 1 and 2 were elucidated by spectroscopic methods. Echinolabdane A (1) possesses a novel tetracyclic skeleton with an oxepane ring jointed to an α,β-unsaturated-γ-lactone ring by a hemiketal moiety, and this compound is the first labdane-type diterpenoid to be obtained from marine organisms belonging to the phylum Cnidaria. 6-epi-Yonarasterol B (2) is the first steroid derivative to be isolated from gorgonian coral belonging to the genus Echinomuricea, and this compound displayed significant inhibitory effects on the generation of superoxide anions and the release of elastase by human neutrophils. Full article
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