Search Results (3)

We aimed to overview the most recent data on sternal metastases from a multidisciplinary approach (diagnosis strategies, outcome, and histological reports). This narrative review based on a PubMed search (between January 2020 and 22 July 2023) using key words such as “sternal”, “manubrium”, and “metastasis” within the title and/or abstract only included original papers that specifically addressed secondary sternal spreading of cancer in adults, for a total of 48 original articles (14 studies and 34 single case reports). A prior unpublished case in point is also introduced (percutaneous incisional biopsy was used to address a 10 cm sternal tumour upon first admission on an apparently healthy male). The studies (n = 14) may be classified into one of three groups: studies addressing the incidence of bone metastases (including sternum) amid different primary cancers, such as prostate cancer (N = 122 with bone metastases, 83% of them with chest wall metastases), head and neck cancers (N = 3620, 0.8% with bone metastases, and 10.34% of this subgroup with sternum involvement); and glioblastoma (N = 92 with bone metastases, 37% of them with non-vertebral metastases, including the sternum); assessment cohorts, including breast cancer (N = 410; accuracy and sensitivity of PET/CT vs. bone scintigraphy is superior with concern to sternum spreading) and bone metastases of unknown origin (N = 83, including a subgroup with sternum metastases; some features of PET/CT help the differentiation with multiple myeloma); and cohorts with various therapeutic approaches, such as palliative arterial embolization (N = 10), thymic neuroendocrine neoplasia (1/5 detected with sternum metastases), survival rates for sternum metastases vs. non-sternum chest wall involvement (N = 87), oligo-metastatic (sternal) breast cancer (3 studies, N = 16 for all of them), oligo-metastatic head and neck cancer (N = 81), conformal radiotherapy (N = 24,215, including an analysis on sternum spreading), and EBRT followed by MR-HIFU (N = 6). Core data coming from the isolated case reports (N = 34) showed a female to male ratio of 1.6; the females’ ages were between 34 and 80 (mean of 57.28) and the males’ ages varied between 33 and 79 (average of 58.78) years. The originating tumour profile revealed that the most frequent types were mammary (N = 8, all females) and thyroid (N = 9, both women and men), followed by bladder (N = 3), lung (N = 2), and kidney (N = 2). There was also one case for each of the following: adenoid cystic carcinoma of the jaw, malignant melanoma, caecum MiNEN, a brain and an extracranial meningioma, tongue carcinoma, cholangiocarcinoma, osteosarcoma, and hepatocellular carcinoma. To our knowledge, this is the most complex and the largest analysis of prior published data within the time frame of our methods. These data open up new perspectives of this intricate, dynamic, and challenging domain of sternum metastases. Awareness is a mandatory factor since the patients may have a complex multidisciplinary medical and/or surgical background or they are admitted for the first time with this condition; thus, the convolute puzzle will start from this newly detected sternal lump. Abbreviations: N = number of patients; n = number of studies; PET/CT = positron emission tomography/computed tomography; EVRT = external beam radiotherapy; MR-HIFU = magnetic resonance-guided high-intensity focused ultrasound; MiNEN = mixed neuroendocrine-non-neuroendocrine tumour. Full article

Word search puzzles are recognized as a valid word recognition task. Eye gaze patterns have been investigated during visual search and reading, but the word search puzzle requires both searching and word recognition. This paper will discuss findings from an eye-tracking study of word search puzzles in three languages, of varying fluency for the participants. Results indicated that participants employ a search strategy that is somewhat dependent on language fluency and varies from a rigid, structured search pattern to randomly searching for a target word. The majority of gaze measurements are not significantly influenced by either word length or fluency of presented language, although mean fixation durations are longer for shorter words. Full article

When nations are violently threatened, the choices that they make in order to cope with the challenge of war reflect different alternative possible reactions. They may choose to fiercely fight their battles; they may prefer to surrender, and sometimes the options lay in-between. One puzzle is, therefore, what makes nations fight, and more importantly—what causes them eventually to win or to lose the war. In search for an answer, this study inquires through secondary sources three historical case studies from World War II: Britain, France and Germany, and reviews how each of these major European powers acted throughout the war. After each historical description, the study examines the part that national ethos played in the manner in which each state handled war in moments of crisis. The national ethos of a people is the creed formed from the shared values and traditions through which the nation views its past, present and future; it is the integrating element that defines a nation’s identity and bonds it into a coherent social group. The study reveals how national ethos is intertwined with another phenomenon of social psychology that turns it into a crucial factor in the management of international campaigns: war enthusiasm. Since national ethos is so crucial for the results of the war that a country might lead in order to survive or prosper, it is imperative for decision makers to bear in mind that it is also subject to a process of shaping and reshaping, as the Soviets have proved in relation to their Russian national ethos during World War II. A word of caution, however, is noteworthy: a wide historical perspective shows that even though the right kind of national ethos is essential for winning a war it is far from being enough. Hence national ethos proves, at the end of the day, to be a necessary condition for military victory but certainly not a sufficient one. Full article