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Keywords = unlocked nucleic acid (UNA)

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26 pages, 3596 KiB  
Review
Acyclic Nucleic Acids with Phosphodiester Linkages—Synthesis, Properties and Potential Applications
by Agnieszka Tomaszewska-Antczak and Piotr Guga
Appl. Sci. 2021, 11(24), 12125; https://doi.org/10.3390/app112412125 - 20 Dec 2021
Cited by 4 | Viewed by 3884
Abstract
This review summarizes the synthetic efforts on acyclic analogs of nucleic acids and provides information on the most interesting features of selected classes of such compounds. The selection includes the following types of analogs: Flexible (FNA), Unlocked (UNA), Glycol (GNA), Butyl (BuNA), Threoninol [...] Read more.
This review summarizes the synthetic efforts on acyclic analogs of nucleic acids and provides information on the most interesting features of selected classes of such compounds. The selection includes the following types of analogs: Flexible (FNA), Unlocked (UNA), Glycol (GNA), Butyl (BuNA), Threoninol (TNA) and Serinol Nucleic Acids (SNA). These classes of analogs are discussed in terms of their synthetic methods, the thermal stability of their homo- and hetero-duplexes and their applicability in biological and biochemical research and nanotechnology. Full article
(This article belongs to the Special Issue Applications of Nucleic Acids in Chemistry and Biology)
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16 pages, 188 KiB  
Review
Locked and Unlocked Nucleosides in Functional Nucleic Acids
by Holger Doessing and Birte Vester
Molecules 2011, 16(6), 4511-4526; https://doi.org/10.3390/molecules16064511 - 27 May 2011
Cited by 42 | Viewed by 10200
Abstract
Nucleic acids are able to adopt a plethora of structures, many of which are of interest in therapeutics, bio- or nanotechnology. However, structural and biochemical stability is a major concern which has been addressed by incorporating a range of modifications and nucleoside derivatives. [...] Read more.
Nucleic acids are able to adopt a plethora of structures, many of which are of interest in therapeutics, bio- or nanotechnology. However, structural and biochemical stability is a major concern which has been addressed by incorporating a range of modifications and nucleoside derivatives. This review summarizes the use of locked nucleic acid (LNA) and un-locked nucleic acid (UNA) monomers in functional nucleic acids such as aptamers, ribozymes, and DNAzymes. Full article
(This article belongs to the Special Issue Nucleoside Analogues)
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